Chronic Heart Failure
Conditions
Brief summary
this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients
Interventions
Low-volume HIIT (LV-HIIT) is a particularly time-efficient subtype of interval training, which has gained increasing attention in recent years. As per the previous definition, these brief training protocols typically involve≤10 min of intense exercise within a session lasting≤30 min including warm-up, recovery phases between intervals, and cool-down
OTHERHigh volume high intensity interval training
long (2-4 min) bouts of high (not maximum) intensity exercise interspersed with recovery periods which have wide varieties in the protocols according to the intensity, duration, and number of intervals performed
DRUGStandard medical treatment
standard medical treatment for chronic heart failure as per international guidlines
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Chronic stable heart failure patient with reduced ejection fraction (EF \<40) 2. Age Above 18 years old 3. Both males and females 4. The ability to provide informed consent
Exclusion criteria
1. Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013) 1. Acute myocardial infarction (MI), within 2 days 2. Ongoing unstable angina 3. Uncontrolled cardiac tachy or brady arrhythmia with hemodynamic compromise 4. Active endocarditis 5. Symptomatic severe aortic stenosis 6. Decompensated heart failure 7. Acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis 8. Acute myocarditis or pericarditis 9. Acute aortic dissection 10. Physical disability that precludes safe and adequate testing or training 11. Known obstructive left main coronary artery stenosis 12. Hypertrophic obstructive cardiomyopathy with severe resting gradient 13. Recent stroke or transient ischemic attack 14. Mental impairment with limited ability to cooperate 15. Resting hypertension with systolic or diastolic blood pressures \>200/110 mmHg 16. Uncorrected medical conditions, such as significant anemia, important electrolyte imbalance, and hyperthyroidism 2. Acute decompensated heart failure NYHA class IV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 6 minute walk test | at enrolment and at the end of treatment at 8 weeks | self-paced submaximal field exercise test to assess submaximal functional capacity of the patient , the distance walked by the patient for six minutes will be measured by meters |
| 2D Echocardiographic parameters | at enrollment and at the end of treatment at 8 weeks | Left ventricle geometry: left ventricular end-diastolic diameter (LVEDD) mm, left ventricular end-systolic diameter (LVESD) mm, left ventricular end-systolic volume (LVESV) ml. and, left ventricular end-diastolic volume (LVEDV) ml. Left ventricle Systolic function: left ventricular ejection fraction (LVEF) % Left ventricle Diastolic function :E wave cm/s: early diastolic mitral inflow velocity, A wave cm/s: diastolic mitral inflow velocity during late atrial contraction , E/A ratio |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Minnesota living with heart failure questionnaire (MLHFQ) | at enrollment and at the end of treatment at 8 weeks | The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is the tool most widely used and recognized to assess HRQOL in adults with Hf, was developed in 1987 by Thomas Rector, focusing on the underlying relationship between pathophysiology, symptoms, functional limitations, and psychological distress, it measures the impacts of symptoms and treatment on different dimensions of HRQOL in HF patients. |
Countries
Egypt
Contacts
Primary ContactAya I Elshenawy
Outcome results
None listed