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Diagnostic Evaluation of Viral Persistence in Cervical Cancer

Personalized, Scientifically Based Technologies in the Diagnosis and Treatment of SARS-CoV-2 as a Possible Cervical Cancer Risk Factor

Status
Enrolling by invitation
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07325682
Acronym
PETCVOCC
Enrollment
30
Registered
2026-01-08
Start date
2025-04-30
Completion date
2030-12-30
Last updated
2026-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Cancer

Keywords

medicament testing, viral antigen persistance, Human Papillomavirus

Brief summary

This study aims to evaluate the diagnostic value of an electroacupuncture-based method for detecting viral persistence (human papillomavirus and SARS-CoV-2) in patients with cervical cancer. The study investigates whether persistent viral signatures can be identified through measurable electrodiagnostic responses at acupuncture points associated with organ systems affected by chronic viral infection. The goal is to assess the feasibility, reproducibility, and potential clinical relevance of this diagnostic approach in oncology patients.

Detailed description

This study investigates the diagnostic potential of an electroacupuncture-based measurement method to detect viral persistence in patients with cervical cancer. Increasing evidence indicates that oncologic processes may be influenced by chronic viral activity, including persistent human papillomavirus (HPV) infection and, in some cases, secondary viral signatures such as SARS-CoV-2. Although HPV is the primary etiologic agent in cervical cancer, clinical observations suggest that long-term viral presence may contribute to variations in disease behavior, immune dysfunction, and treatment response. The diagnostic method used in this study is based on measurement of electrical parameters at standardized acupuncture points. These points are functionally connected to organ systems involved in chronic viral disease. Changes in their electrical characteristics may reflect physiological responses associated with viral persistence. The technique has been previously developed and refined in clinical practice and has demonstrated reproducibility in identifying characteristic response patterns in patients with viral and post-viral conditions. This study aims to evaluate whether measurable electrodiagnostic responses correlate with persistent viral signatures in cervical cancer patients. All participants undergo standardized diagnostic measurements performed under controlled conditions. The study does not involve therapeutic intervention, drug administration, or device implantation. Only diagnostic data are collected. The primary objective is to assess whether this method can reliably identify patterns consistent with viral persistence. Secondary objectives include evaluating repeatability of measurements, describing characteristic profiles in this patient population, and assessing feasibility of integrating this diagnostic approach into clinical oncology settings. This research is expected to contribute to a better understanding of viral involvement in cancer microenvironments and to support the development of non-invasive diagnostic tools for evaluating viral activity in oncologic patients.

Interventions

DIAGNOSTIC_TESTElectroacupuncture

Non-invasive electrodiagnostic assessment using electroacupuncture measurements to evaluate bioelectrical response patterns associated with viral markers in patients with cervical cancer.

Sponsors

Oncology Center,Ministry Of Heath,Uzbekistan
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Masking description

Diagnostic evaluation of viral persistence using EAV-based measurement of viral activity in cervical cancer patients.

Eligibility

Sex/Gender
FEMALE
Age
21 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* Histologically confirmed cervical cancer (FIGO stage IIIA-IVA) * Age ≥21 years * ECOG performance status adequate for diagnostic procedures * Adequate organ function * Ability to provide informed consent

Exclusion criteria

* Poor renal function (elevated creatinine) * Significant liver dysfunction (elevated bilirubin or liver enzymes) * Severe cardiovascular or pulmonary disease * Pregnancy or breastfeeding * Severe mental illness or inability to provide informed consent * Known non-compliance or substance abuse

Design outcomes

Primary

MeasureTime frameDescription
Number of Participants With Bioelectrical Patterns Consistent With Viral Antigen PersistenceAt enrollment (single diagnostic session)Diagnostic assessment to identify bioelectrical response patterns associated with viral antigen persistence in cervical cancer patients using a non-invasive bioelectrical testing approach.

Countries

Uzbekistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026