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Neuromuscular Training in Professional Esports Players

Effectiveness of Neuromuscular Training Added to Routine Practice on Fatigue and Stress Biomarkers in Professional Esports Players: A Randomized Controlled Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07325396
Enrollment
24
Registered
2026-01-08
Start date
2026-01-28
Completion date
2026-12-01
Last updated
2026-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esports, Esports Players

Keywords

esports, professional gamers, neuromuscular training, fatigue, stress, biomarkers

Brief summary

Professional esports players engage in prolonged training sessions and experience high physical and mental stress due to intensive competition schedules. These demands can lead to increased fatigue, decreased performance, and health problems. This randomized controlled trial aims to investigate whether adding a structured neuromuscular exercise program to routine esports training reduces fatigue and stress biomarkers and improves performance-related outcomes in professional esports players.

Detailed description

Esports players often perform long hours of training that require sustained physical and cognitive effort, which may result in musculoskeletal problems, mental fatigue, and elevated stress levels. Most studies in the esports field rely on subjective evaluations and include non-professional populations. Objective assessment of fatigue and stress biomarkers in professional esports athletes is still lacking. This prospective randomized controlled trial will include 24 professional esports players aged 18-35 who train at least 35 hours per week with their teams. Participants will be randomly assigned to either a neuromuscular training group or a control group. The intervention group will complete an 8-week neuromuscular exercise program three times per week in addition to their regular esports training routine. The control group will receive structured physical activity counseling based on ACSM 5A principles. Primary outcomes include serum levels of cortisol, testosterone, testosterone/cortisol ratio, C-reactive protein (CRP), creatine kinase (CK), vitamin B12, and ferritin measured under standardized fasting conditions. Secondary outcomes include muscle strength (myometry), sleep quality (Pittsburgh Sleep Quality Index), physical activity level (IPAQ-SF), quality of life (SF-12), visual and auditory reaction time tests, lactate measures (Lactate Scout), and mood states (POMS). Outcomes will be assessed at baseline and after the 8-week intervention period. The findings of this study are expected to provide evidence-based recommendations for integrating neuromuscular conditioning into professional esports training to enhance physical health, reduce fatigue and stress, and improve overall performance.

Interventions

BEHAVIORALNeuromuscular Training

A progressive neuromuscular exercise program including dynamic warm-up, aerobic exercises, functional strengthening of lower and upper extremity muscles, core stabilization training, and reaction drills performed 3 times per week for 8 weeks. Duration and repetitions increase biweekly according to a structured progression protocol.

BEHAVIORALPhysical Activity Counseling

Structured physical activity counseling based on ACSM 5A principles (Assess, Advise, Agree, Assist, Arrange) delivered weekly for 8 weeks to promote sustainable physical activity behaviors and reduce sedentary time during esports training routines.

Sponsors

Yeditepe University
Lead SponsorOTHER
Istanbul University - Cerrahpasa
CollaboratorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Eligibility

Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Age between 18-35 years * Currently competing as a contracted professional esports player * Playing one of the following games at a professional level: League of Legends, Counter Strike 2, Overwatch, Valorant, Apex Legends, DOTA2, Rocket League, PUBG * Participating in ≥35 hours/week of training with their team * Voluntary agreement to participate and sign informed consent

Exclusion criteria

* History or presence of medical conditions affecting safety or performance: metabolic, cardiovascular, renal, neurological, or respiratory disorders * Playing esports only at amateur or beginner level * Answering "Yes" to any item in the Physical Activity Readiness Questionnaire (PAR-Q) Removal Criteria: * Participating in \<35 hours/week esports training during the study * Missing ≥2 neuromuscular training sessions (intervention group) * Leaving their professional esports organization (roster removal, retirement, etc.) * Any illness or injury preventing continuation of esports participation

Design outcomes

Primary

MeasureTime frameDescription
Serum cortisol level - Stress BiomarkersBaseline and 8 weeksSerum cortisol level will be analyzed under fasting conditions using standardized laboratory protocols.
Testosterone level - Stress BiomarkersBaseline and 8 weeksTestosterone level will be analyzed under fasting conditions using standardized laboratory protocols.
C-Reactive Protein Level (CRP) - Fatigue BiomarkersBaseline and 8 weeksSerum CRP levels will be analyzed under fasting conditions using standardized laboratory protocols.
Creatine Kinase (CK) Level - Fatigue BiomarkersBaseline and 8 weeks.Creatine kinase levels will be analyzed under fasting conditions using standardized laboratory protocols.
Vitamin B12 Level - Fatigue BiomarkersBaseline and 8 weeks.Serum vitamin B12 levels will be analyzed under fasting conditions using standardized laboratory protocols.
Ferritin Level - Fatigue BiomarkersBaseline and 8 weeks.Serum ferritin levels will be analyzed under fasting conditions using standardized laboratory protocols.

Secondary

MeasureTime frameDescription
Muscle StrengthBaseline and 8 weeksHand, forearm, shoulder, and back muscle strength will be assessed using a handheld myometer; mean of three trials recorded in kilograms.
Sleep QualityBaseline and 8 weeksAssessment of subjective sleep quality, sleep duration, sleep disturbances, and overall sleep efficiency with Pittsburgh Sleep Quality Index. The Pittsburgh Sleep Quality Index (PSQI) consists of 19 items that generate seven component scores, each ranging from 0 to 3, yielding a global score between 0 and 21, with higher scores indicating poorer sleep quality; a total score greater than 5 reflects clinically significant sleep disturbance.
Physical Activity LevelBaseline and 8 weeksSelf-reported physical activity levels converted to MET-minutes per week. (IPAQ-Short Form). The International Physical Activity Questionnaire-Short Form (IPAQ-SF) provides total physical activity expressed in Metabolic Equivalent of Task (MET)-minutes/week, and scores are categorized as follows: \<600 MET-minutes/week indicates low activity, 600-3000 MET-minutes/week indicates moderate activity, and \>3000 MET-minutes/week indicates high physical activity level.
Reaction TimeBaseline and 8 weeksAverage visual reaction time over 5 trials recorded in milliseconds. Average response latency to an auditory stimulus over 5 trials.
Blood Lactate ConcentrationBaseline, 4 weeks and 8 weeksCapillary blood lactate measured to assess metabolic response to neuromuscular training.
Mood StateBaseline and 8 weeksAssessment of tension, depression, anger, fatigue, and vigor subscales with Profile of Mood States (POMS). The Profile of Mood States (POMS) assesses mood across multiple dimensions and yields a Total Mood Disturbance (TMD) score by summing negative mood subscales and subtracting the vigor score; higher TMD scores indicate greater mood disturbance, whereas lower scores reflect better overall mood.

Countries

Turkey (Türkiye)

Contacts

CONTACTDoğukan Tongar, Master of Science
doguka.tongar@yeditepe.edu.tr+90 0507 843 10 21
CONTACTEla TARAKCI
etarakci@iuc.edu.tr

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 11, 2026