Diabetic Gastroparesis
Conditions
Keywords
Diabetic gastroparesis, Advanced glycation end products
Brief summary
This study is a prospective observational study. The study will explore the correlation between advanced glycation end products and gastric motility disorder in diabetic gastroparesis（DGP) through the collection of blood and gastric tissue samples and relevant data of patients with DGP and control group patients without diabetes history and gastroparesis symptoms.
Detailed description
This study will collect the gastric smooth muscle tissue and serum of patients with diabetic gastroparesis（DGP) and control group patients without diabetes history and gastroparesis symptoms, and collect the following patient related information: age, gender, height, weight, fasting blood glucose, diabetes course, glycosylated hemoglobin, fasting C-peptide, serum creatinine, and electrogastrogram results. The study will compare the score of gastroparesis cardinal symptom index scale and electrogastrogram results of patients with DGP and and control group patients without diabetes history and gastroparesis symptoms, detect and compare the difference in the expression of contractile protein in the muscle layer of gastric tissue of the two groups, detect and compare the difference in advanced glycation end products (AGEs) of serum and gastric tissue of the two groups, and analyze the correlation between serum and gastric tissue AGEs and clinical symptoms. Through the above results, we will clarify the correlation between AGEs and gastric motility disorders in DGP.
Interventions
None listed
Sponsors
Northern Jiangsu People's Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
for diabetes gastroparesis group: * Meet the diagnostic criteria for diabetes * Presence of symptoms (see assessment of Gastroparesis Cardinal Symptom Index) * Age range from 18 to 75 years old * Voluntarily participate and sign an informed consent form Inclusion Criteria for control group: * No history of diabetes * No symptoms (see assessment of Gastroparesis Cardinal Symptom Index) * Age range from 18 to 75 years old * Voluntarily participate and sign an informed consent form
Exclusion criteria
for diabetes gastroparesis group and control group: * Currently taking prokinetic drugs, anticholinergic drugs, and dopamine drugs that may affect gastric motility * Has a history of gastrointestinal surgery * Pregnant or preparing to conceive * There are neurological disorders such as Parkinson's disease that affect gastrointestinal function * Outlet obstruction caused by organic lesions in the pylorus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gastroparesis Cardinal Symptom Index (GCSI) score | The day when the subjects were enrolled | The Gastroparesis Cardinal Symptom Index (GCSI) is a patient-reported outcome measure used to assess the severity of gastroparesis symptoms. It consists of nine items grouped into three subscales: postprandial fullness/early satiety, nausea/vomiting, and bloating. Patients rate the severity of each symptom on a scale from 0 (no symptom) to 5 (very severe). The GCSI score is calculated as an average score of all three symptom categories. It is a reliable and valid tool for evaluating symptom severity and treatment effectiveness in clinical trials and other studies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The results of electrogastrogram | On the day of the subject's electrogastrogram examination | The results of electrogastrogram mainly include the frequency and amplitude of slow waves, the proportion of gastric electrical rhythm disturbances, and the proportion of normal slow waves in the electrogastrogram. |
Countries
China
Contacts
CONTACTYing Zhu, Doctor's degree
PRINCIPAL_INVESTIGATORYing Zhu, Doctor's degree
Northern Jiangsu People's Hospital
Outcome results
None listed