Diagnostic Value, Transcranial Doppler Ultrasound, Neonatal Craniocerebral Injuries
Conditions
Brief summary
This study aims to evaluate the diagnostic value of transcranial Doppler ultrasonography (TCD) for evaluating neonatal craniocerebral injuries.
Detailed description
A high-risk neonate refers to an infant, irrespective of gestational age or birth weight, who exhibits an elevated likelihood of experiencing health complications or death. Preterm infants, defined as those born alive at a gestational age of less than 37 weeks, have seen increased birth and survival rates due to advancements in medical technology and the widespread establishment of Neonatal Intensive Care Units (NICUs). Neonatal sepsis is one of the leading causes of morbidity and mortality among term and preterm infants worldwide. Transcranial Doppler ultrasonography (TCD) is the only noninvasive method that enables reliable evaluation of blood flow in the basal intracerebral vessels, providing physiological information complementary to anatomic imaging. TCD is relatively inexpensive, can be performed at the bedside, and enables monitoring in acute emergency settings and for prolonged periods with high temporal resolution, making it ideal for studying dynamic cerebrovascular responses.
Interventions
Trans-cranial ultrasound will be carried out for assessment of blood flow velocity in the anterior \[ACA\] and middle cerebral arteries \[MCA\] using duplex pulsed Doppler ultrasound.
Sponsors
Kafrelsheikh University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 37 Weeks
Healthy volunteers
No
Inclusion criteria
* Both sexes. * High-risk neonates with any of the following: * Critically ill neonates. * Neonatal sepsis. * Neonatal encephalopathy includes hypoxic-ischemic encephalopathy. * Respiratory distress. * Neonatal seizures. * Birth asphyxia. * Signs and or symptoms of central nervous system disorders like microcephaly, macrocephaly, hypotonia, unexplained poor feeding, * Neonates born out of traumatic/instrumental labor. * Suspected metabolic disturbances. * Neonates with low APGAR score (\<7). * Neonates with low birth weight (\<2.5 kg).
Exclusion criteria
* Congenital malformations. * Genetic metabolic diseases or other severe complications. * Severe intrauterine infection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity of transcranial Doppler ultrasound | 6 months post-procedure | The sensitivity of transcranial Doppler ultrasound in diagnosing brain injury will be recorded |
Countries
Egypt
Contacts
Primary ContactNeamat M Omar, MBBCH
Outcome results
None listed