Ultra-early Chest CT for SAP Prediction

Ultra-early Chest CT Improves Risk Prediction of Stroke-associated Pneumonia: Model Development and External Validation in a Multicentre Retrospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07321275

Acronym

SENTRY

Enrollment

1499

Registered

2026-01-07

Start date

2026-01-15

Completion date

2026-02-19

Last updated

2026-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Ischaemic Stroke, Stroke-associated Pneumonia

Keywords

Acute ischaemic stroke, Stroke-associated pneumonia, Risk prediction model

Brief summary

Stroke-associated pneumonia (SAP) is a common and serious complication after acute ischaemic stroke (AIS). Existing scores rely mainly on clinical variables, and the added prognostic value of inflammatory markers and early chest CT findings remains uncertain. We developed and externally validated an early multimodal model combining clinical severity, inflammation, and chest CT abnormalities, and explored risk-stratified associations between prophylactic antibiotics and SAP.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. patients aged ≥18 years; 2. Admitted to a participating stroke centre with neuroimaging-confirmed acute ischaemic stroke ; 3. Had chest CT performed within 24 hours of stroke onset.

Exclusion criteria

1. Pneumonia; 2. Chest CT images unavailable or incomplete for assessment; 3. Insufficient clinical documentation to ascertain stroke-associated pneumonia occurrence within 7 days after stroke onset

Design outcomes

Primary

Measure	Time frame	Description
Stroke-associated pneumonia	within 7 days after stroke onset	SAP was defined as pneumonia occurring within 7 days after stroke onset. Potential events were screened using discharge diagnosis codes and medical record documentation, and then confirmed by manual chart review using prespecified clinical, laboratory, and radiological criteria consistent with the Pneumonia in Stroke Consensus Group and modified CDC definitions.

Countries

China

Outcome results