Effect of Hands and Feet Exercises on Taxane Based Chemotherapy Induced Peripheral Neuropathy in Patients With Solid Tumors

Peripheral Neuropathy

Peripheral neuropathy, Taxane, Chemotherapy

The goal of this clinical trial is to determine whether hand and foot exercises can reduce the severity of Taxane-based chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer patients aged 20-60 years who have Grade 1I neuropathy as defined by the NCI-CTCAE criteria. The main questions it aims to answer are: * Do hand and foot exercises reduce the severity of sensory and motor neuropathic symptoms in patients receiving Taxane based chemotherapy? * Is the severity of peripheral neuropathy lower in the exercise group compared to patients receiving standard care alone? Researchers will compare patients receiving standard care (control group) with those receiving standard care plus a structured hand and foot exercise program (experimental group) to see if the exercises lead to greater improvement in neuropathy severity scores. Participants will: * Receive baseline assessment using the EORTC QLQ-CIPN20 questionnaire. * In the experimental group, learn and perform a 15-minute hand and foot exercise routine on chemotherapy day and continue it at home using a provided brochure. * Participate in telephonic follow-ups to support compliance and monitor symptoms. * Undergo a follow-up assessment at alternate week to measure changes in neuropathy severity.

The study focuses on adults between 20 and 60 years old who are receiving Taxane chemotherapy and have early-stage (Grade II) neuropathy. At this stage, patients usually notice changes in sensation, but these changes are still manageable. By starting exercises early, the study aims to see whether regular movement of the hands and feet can help reduce the intensity of these symptoms over time. Participants will be randomly assigned to one of two groups. One group will continue with their routine medical care for neuropathy, which may include medication and guidance from their healthcare team. The other group will receive the same standard care but will also be taught a short set of hand and foot exercises. These exercises take around 15 minutes to complete and are performed once a day. Patients in the exercise group will first learn the routine on the day of their chemotherapy session and will receive a brochure so they can continue the exercises at home. Telephone check-ins will be used to support patients, answer questions, and encourage regular practice. To understand how symptoms change, all participants will complete a questionnaire called the EORTC QLQ-CIPN20 at the beginning of the study and again after several weeks. This tool helps measure nerve-related symptoms and how much they affect daily life. The results will allow the research team to compare how symptoms change in both groups over the course of the study. By examining whether a simple, low-cost exercise routine can make a meaningful difference, this study hopes to offer cancer patients a practical way to manage neuropathy alongside their chemotherapy. If effective, these exercises could become a helpful addition to supportive care in oncology settings, improving comfort and quality of life during treatment.

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