Emotion
Conditions
Keywords
Biomarkers, Stimuli, Related
Brief summary
Recent studies show that emotional states can be discriminated by physiological responses. This physiological regulation results from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers, using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state in response to stimuli, particularly olfactory stimuli.
Detailed description
Recent studies show that emotional states (positive and negative) can be discriminated by physiological responses. This physiological regulation stems from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers (enzymes, hormones), using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state (Giacomello et al. 2020) in response to stimuli, particularly olfactory stimuli. The aim of the proposed research is to identify and measure a signature of molecular biomarkers in saliva, linked to emotions following one or more olfactory stimuli (e.g. cortisol and alpha-amylase concentration increase after stimulation).
Interventions
OTHERIdentication and measurement of a molecular biomarkers signature
Levels of the biomarkers of interest (DHEA, pg/mL; Oxytocin, pg/mL; Cortisol, pg/mL; Alpha Amylase, U/mL) will be measured in the saliva of participating subjects by enzymatic assay methods or ELISA-type methods performed using commercial kits.
Sponsors
Sys2Diag
Centre National de la Recherche Scientifique, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Subject willing to follow study procedures * Subject able to understand the purpose, nature and methodology of the study * Subject has signed informed consent form * Subjects between 18 and 60 years of age.
Exclusion criteria
* Subjects deprived of liberty, protected adults, vulnerable persons or minors * Subjects with a proven or suspected chronic infectious disease that could entail a risk of contamination during sample handling (laboratories not equipped to handle this type of sample) * Rejection to sign the consent form. Non specific inclusion criteria: * Pregnant or breastfeeding women * Subjects presenting anosmia during the last 15 days * Subjects presenting symptoms and signs of active oral inflammation, advanced periodontitis or severe gingivitis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate variations | 1 year | Evaluate variations in several molecular biomarkers in saliva following fragrance stimulus/stimuli that may be linked to an emotionnal response (positive or negative). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identify a molecular biomarker signature | 2 years | Identify a molecular biomarker signature in saliva following fragrance stimulus or stimuli. |
| Evaluate basal values of biomarkers | 3 years | Evaluate basal values of biomarkers composing the signature under normal, unstimulated conditions (intra-individual, inter-individual variations, circadian rhythm, age, gender...). |
| Evaluate signature dynamics | 1 year | Evaluate signature dynamics after stimulation |
| Establish correlations between biomarker signatures and emotion ratings | 3 years | Establish correlations between biomarker signatures and emotion ratings based on other criteria, such as questionnaires. |
| Compare biomarker signatures | 2 years | Compare biomarker signatures in response to different fragrance stimuli. |
Countries
France
Contacts
CONTACTWendpouiré A OUEDRAOGO, Msc
PRINCIPAL_INVESTIGATORLaurence MOLINA, Phd
Sys2Diag
Outcome results
None listed