Accelerated Rehabilitation in Individuals After Total Knee Arthroplasty

Effectiveness of Accelerated Rehabilitation on Knee Joint Function and Quality of Life in Individuals With Total Knee Arthroplasty: A Double Blind Randomized Controlled Trial

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07319546

Enrollment

Registered

2026-01-06

Start date

2025-12-01

Completion date

2027-06-30

Last updated

2026-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthroplasties, Knee Replacement, Knee Osteoarthristis

Brief summary

The primary aim of this double-blind randomized controlled trial is to evaluate the effectiveness of an accelerated rehabilitation protocol on knee joint function and quality of life in individuals undergoing TKA compared to conventional rehabilitation in Dali, Yunan, China. The study will include patients aged 50-80 years who are scheduled for primary unilateral TKA. Participants will be randomly assigned to either an accelerated rehabilitation group or conventional rehabilitation group. The primary outcomes will include knee joint function, assessed using the KOOS and quality of life measures using the SF-36 surveys. The study will follow participants for 6 months post-surgery to assess longer-term outcomes. This study will not include individuals undergoing revision TKA or those with severe comorbid conditions. The results will provide critical insights into the role of accelerated rehabilitation in improving post-operative recovery, functional outcomes, and overall quality of life for TKA patients.

Interventions

BEHAVIORALAccelerated exercise

Based on optimal and accelerated concepts

BEHAVIORALRoutine exercise

Conventional program

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients diagnosed with end-stage knee OA necessitating primary unilateral TKA.

Exclusion criteria

* History of joint infections, cancer, or inflammatory arthritis. * End-stage OA from rheumatoid or septic arthritis. * Individuals with neurological disorders such as Alzheimer's disease, - Parkinson's disease, stroke. * Individuals who are unable to follow a structured rehabilitation protocol. * Previous history of knee surgeries (other than arthroscopy). * Severe comorbidities that would hinder participation (e.g., advanced cardiovascular diseases). * Individuals who have severe osteoporosis.

Design outcomes

Primary

Measure	Time frame
Knee injury and Osteoarthritis Outcome Score (KOOS)	From enrollment to the end of 6-month follow-up

Countries

China

Contacts

Primary ContactLiying Yang, PT, M.Sc.

liying.yan@student.mahidol.ac.th+86 18787638700

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026