Mild Cognitive Impairment
Conditions
Brief summary
In this within-subjects, crossover study, participants will undergo Electroencephalogram (EEG) recordings before, during, and after each of three 1-hour sessions. All participants will experience all three conditions: (1) dual-frequency visual (10 and 40 Hz), (2) single-frequency visual (40 Hz), and (3) non-rhythmic stimulation. EEG spectral power and amplitude coupling will be analyzed to determine whether stimulation-induced increases in alpha-gamma neural synchrony translate to improvements in cognitive performance.
Interventions
DEVICEFlickering Light
Red Flickering Light programed to three different visual stimulations
Sponsors
Icahn School of Medicine at Mount Sinai
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
55 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* History of Mild Cognitive Impairment with a Montreal Cognitive Assessment score between 18 and 25
Exclusion criteria
* History of epilepsy or photosensitivity * Blindness or other obstructive vision conditions * retinal diseases * presence of another brain disease accounting for their cognitive status
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG-based neural synchrony | 5 minute EEG recording will be done at start, middle and end of each one-hour session, each session separated by one week | Change in spectral power and amplitude in the alpha and gamma EEG bands. Increase in power and amplitude is indicative of increases in neural synchrony. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Digit Span Task | Completed at start and end of each one-hour session, each session will be separated by one week | Change in cognition will be measured by the Digit Span Task which is a working memory task. Increase in accuracy and response time indicates improved cognitive performance. Digit Span. Memory span is the longest list of items that a person can repeat back in correct order immediately after presentation on 50% of all trials. Items may include words, numbers, or letters. The task is known as digit span when numbers are used. Memory span is a common measure of short-term memory. A digit-span task is used to measure working memory's number storage capacity. The item score is the sum of the scores on the two trials for that item (range=0-2). The total raw score for backwards digit span is the sum of the item scores; maximum backwards digit span total raw score is 16 points. Higher score indicates better health outcomes. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMariana Figueiro, PhD
Icahn School of Medicine at Mount Sinai
Outcome results
None listed