Sensitivity to Ovarian Hormones and Depression in Adolescents

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07317895

Acronym

SOHDA

Enrollment

Registered

2026-01-05

Start date

2026-03-01

Completion date

2027-08-31

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depressed

Keywords

Depression, Estrogen, Progesterone

Brief summary

The goal of this observational study is to learn about the relationship between changes in ovarian hormones (estrogen and progesterone) and adolescent depression. The main question it aims to answer is: Can we identify a subset adolescents assigned female at birth with a history of depression who are particularly sensitive to changes in ovarian hormones? Participants will be monitoring daily absolute ovarian hormone levels at home using the Mira Analyzer and answer online survey questions about their mental health for 90 days.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

12 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Assigned female at birth, at least 1 year post-menarche, naturally cycling, history of depression or symptoms of depression, and able to read and write in English.

Exclusion criteria

* Pregnant or taking any hormonal or cycle altering medications/devices.

Design outcomes

Primary

Measure	Time frame	Description
Identification ovarian hormone affect sensitivity	90 days	Identify depressed adolescents assigned female at birth with depressed affect sensitivity to changes in ovarian hormones across the menstrual cycle.

Countries

Canada

Contacts

Primary ContactWhitney Hindmarch, PhD

whitney.hindmarch@ucalgary.ca587-534-7260

Outcome results