Ayahuasca, Esketamine and Premenstrual Symptoms

Effects of a Single Dose of Ayahuasca or Esketamine on the Menstrual Cycle and Premenstrual Symptoms: a Randomized, Double-Blind Study

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07317232

Enrollment

Registered

2026-01-05

Start date

2025-12-20

Completion date

2026-07-31

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Women Volunteers

Brief summary

Double-blind, randomized trial comparing a single dose of oral ayahuasca or esketamine on premenstrual symptoms.

Interventions

DRUGAyahuasca

oral ayahuasca

DRUGEsketamine

oral esketamine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers

Exclusion criteria

* psychiatric and other medical comorbidities

Design outcomes

Primary

Measure	Time frame	Description
Premenstrual Symptom Tracking Instrument (PSST)	From enrollment to the end of treatment at 3 weeks	higher scores mean a worse outcome

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026