Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis

Clinical and Biochemical Evaluation of Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management of Stage II Grade A Periodontitis: A Randomized Controlled Clinical Trial

Status

Enrolling by invitation

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07316582

Enrollment

Registered

2026-01-05

Start date

2025-11-01

Completion date

2026-07-01

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis Stage II

Brief summary

melatonin loaded in injectible platelet rich fibrin in treatment of periodontitis

Interventions

DRUGMelatonin-Loaded Injectable Platelet-Rich Fibrin

patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection

BIOLOGICALinjectible platelet rich fibrin (i-PRF )

patients will be included in this group receiving (SRP) with local application of i-PRF

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

\- Diagnosed with stage II periodontitis based on AAP/EFP 2018 classification • Minimum of two non-adjacent periodontal pockets \<5 mm in different quadrants • Systemically healthy individuals willing to participate and comply with follow-up visits • Radiographic bone loss (ranged from is 10-20% mostly horizontal

Exclusion criteria

History of systemic diseases affecting periodontium (e.g., diabetes, osteoporosis) • Use of antibiotics, anti-inflammatories, or antioxidant supplements in the past 3 months • Smoking or tobacco use • Pregnancy or lactation • Allergy to melatonin or related compounds \-

Design outcomes

Primary

Measure	Time frame
Clinical attachment level (CAL)	6 months

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026