Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07316452

Enrollment

10000

Registered

2026-01-05

Start date

2025-01-01

Completion date

2028-01-01

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Disease, Young Adult

Brief summary

This study is part of a nationwide research project in China that aims to better understand how coronary artery disease develops and progresses in young adults. The study will enroll approximately 10,000 participants aged 45 years or younger who undergo coronary CT scans at multiple hospitals across China. Information collected at enrollment includes basic health information, cardiovascular risk factors, blood test results, medication use, lifestyle habits, and, for some participants, genetic data. Participants will undergo follow-up coronary CT scans after several years to evaluate changes in coronary artery plaque and disease progression. By analyzing these clinical and imaging data, the study aims to identify factors associated with disease progression and to develop prediction models that may help estimate an individual's future risk of coronary plaque progression and cardiovascular events. The results of this study may contribute to improved risk assessment and early prevention strategies for coronary artery disease in young populations.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

1. Age between 18 and 45 years at the time of enrollment. 2. Presence of symptoms suggestive of coronary artery disease and completion of coronary computed tomography (CT) examination. 3. Ability and willingness to provide written informed consent and to participate in follow-up assessments.

Exclusion criteria

1. Inability or unwillingness to complete follow-up assessments. 2. Inability to provide written informed consent. 3. History of coronary revascularization, including percutaneous coronary intervention or coronary artery bypass grafting. 4. Poor-quality coronary computed tomography images that are inadequate for reliable plaque assessment. 5. Presence of severe systemic disease with limited life expectancy that may interfere with study follow-up. 6. Pregnant or breastfeeding women. 7. Participation in another clinical study that may interfere with the outcomes of this study.

Design outcomes

Primary

Measure	Time frame	Description
Progression of Coronary Plaque on Computed Tomography	From baseline to follow-up coronary CT, up to 3 years	Progression of coronary atherosclerotic plaque assessed by comparing baseline and follow-up coronary computed tomography scans.

Countries

China

Contacts

Primary ContactZhihui Hou, MD, PhD

konglingyihui@126.com+86 15011451210

Outcome results