fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Preeclampsia

A Prospective Study of Validation of the fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Women With Pre- Eclampsia in Sohag University Hospital

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07316140

Acronym

Aprospective

Enrollment

Registered

2026-01-05

Start date

2026-01-01

Completion date

2026-09-01

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fullpairs, Preeclampsia

Keywords

Fullpairs score, Fullpairs, Preeclampsia

Brief summary

Apredictive formula, fullPIERS (Pre-eclampsia Integrated Estimate of Risk Score), can be used to estimate the risk of suffering an adverse outcome using information obtained within 48 hours of admission with pre-eclampsia. The following information is used, serum creatinine, gestational age, platelet count,

Detailed description

Inclusion criteria Patients diagnosed with preeclampsia, defined by hypertension (systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg, measured twice more than 4 hours apart after 20 weeks gestation) Proteinuria of at least 0.3 g/dl or ≥300 mg of protein in a 24-hour urine collection Urine albumin-creatinine ratio (ACR) ≥30 mg/mmol, or hypertension with end organ dysfunction after20 weeks gestation

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* Inclusion Criteria Female patients diagnosed with preeclampsia. Gestational age ≥ 20 weeks. Hypertension defined as: Systolic blood pressure ≥ 140 mmHg and/or Diastolic blood pressure ≥ 90 mmHg, measured on at least two occasions more than 4 hours apart. Proteinuria defined as: * 300 mg protein in a 24-hour urine collection or * 0.3 g/dL on urine analysis. Singleton pregnancy.

Exclusion criteria

Patients who do not meet the clinical or laboratory diagnostic criteria of preeclampsia.

Design outcomes

Primary

Measure	Time frame	Description
Validation of the fullPIERS prediction model for adverse maternal outcomes using logistic regression-derived predicted probabilities	1year	—
Evaluate the validity of the fullPIERS model in the prediction of adverse maternal outcomes in women with pre-eclampsia in Sohag Governorate, Egypt.	1year	The collected data are then will be used to calculate the predicted probability of adverse outcomes using the fullPIERS logistic regression equation logit(p)=2.68+(-5.41×10-2×gestational age) +1.23×(chest pain or dyspnea)+(-2.71×10 -2×creatinine) .

Countries

Egypt

Outcome results