Atherosclerotic Cardiovascular Disease (ASCVD), Rheumatoid Arthritis (RA
Conditions
Keywords
CAT-RA
Brief summary
Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.
Detailed description
The objective of this study is to test the utility of high sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) in risk stratifying patients with rheumatoid arthritis (RA) who may benefit from lipid lowering therapy. The population of interest are individuals who would not otherwise be recommended for therapy based on general population risk calculators for heart disease risk.
Interventions
DIAGNOSTIC_TESThigh sensitivity cardiac troponin
Blood measurement of high sensitivity cardiac troponin
Sponsors
Brigham and Women's Hospital
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
35 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* RA diagnosed by a rheumatologist * Age 40- 79 * ≥1 ASCVD risk factor including prediabetes, hypertension, BMI \>30, current or history of cigarette smoking
Exclusion criteria
* Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor * Patients with diabetes mellitus * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| coronary artery calcium score | Cross-sectional, at baseline | Quantified coronary artery calcium score |
Countries
United States
Outcome results
None listed