Generally Healthy Adults Over 60 Years Old
Conditions
Brief summary
The aim this study is to investigate the effects of time-restricted eating (TRE) on body composition, muscle function and markers of metabolic health of adults over 60 years old. This study will compare different variations of TRE - with and without an additional protein. This study involves attending two study days at the University of Surrey for baseline and end-of-intervention measurement of body composition using a gold-standard dual energy x-ray absorptiometry (DEXA) scan; muscle function using hand grip strength and 30-second sit-to-stand tests; weight. A blood sample will be taken at each study visit to measure markers of lipid and glucose control, and insulin sensitivity. Participants will be randomly allocated to one of four study groups: * control group: maintain habitual dietary patterns * TRE group: fast for 16 hours overnight, eat between 12-8pm * TRE + Protein (AM): fast for 16 hours overnight, eat between 12-8pm; take a 30g plant-based protein supplement in the morning * TRE + Protein (PM): fast for 16 hours overnight, eat between 12-8pm; take a 30g plant-based protein supplement in the afternoon Participants will be asked to follow the intervention according to their allocated group for 8 weeks.
Interventions
OTHERTRE
* Participants will be asked to follow a 16:8 TRE protocol, consuming all their daily within 8 hours, between 12 and 8pm, and fast for 16 hours overnight. * Outside of the eating window, participants will be allowed to consume energy-free drinks only, i.e. water, black tea/coffee, 0-calorie soft drinks.
OTHERProtAM TRE
* Participants will be asked to follow a 16:8 TRE protocol, consuming all their daily within 8 hours, between 12 and 8pm, and fast for 16 hours overnight. * Outside of the eating window, participants will be allowed to consume energy-free drinks only, i.e. water, black tea/coffee, 0-calorie soft drinks. * In addition, they will be asked to consume a protein drink containing 30g protein in the morning, 2 hours before the 8-hour eating window opens at 12pm (i.e. at 10am).
OTHERProtPM TRE
* Participants will be asked to follow a 16:8 TRE protocol, consuming all their daily within 8 hours, between 12 and 8pm, and fast for 16 hours overnight. * Outside of the eating window, participants will be allowed to consume energy-free drinks only, i.e. water, black tea/coffee, 0-calorie soft drinks. * In addition, they will be asked to consume a protein drink containing 30g protein in the afternoon, either 2 hours after their first meal or 2 hours before their last meal of the day.
Sponsors
University of Surrey
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Gender: male and female * Age range: 60 years or older * Fasting for 12 or less hours on a daily basis * BMI range: 23-30 kg/m2 * Weight stability: no more than 3kg weight gain or loss in the past 3 months * Regular eating pattern, i.e. 3 meals a day * Able to prepare the protein supplement
Exclusion criteria
* Any of the following present (in line with
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in body composition at 2 months using whole-body dual-energy x-ray absorptiometry (DEXA) | For 8 weeks of the assigned study intervention | Measured using whole-body dual-energy x-ray absorptiometry (DEXA) In addition to the above, body composition will also be assessed using Tanita Bioelectrical impedance analysis (BIA). Fat free and fat mass will be reported in kg. |
| Change from baseline in muscle function at 2 months | At the start and end of 8 weeks of the assigned study intervention | Measured using grip strength |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in lipid metabolism at 2 months | At the start and end of 8 weeks of the assigned study intervention | fasting total, LDL- and HDL cholesterol and triglyerides |
| Change in fasting glucose control indicators | At the start and end of 8 weeks of the assigned study intervention | HbA1c |
| Feasibility of the assigned TRE intervention | at the end of the 8 week intervention | semi-structured interviews |
| Change from baseline in diet composition at 2 months | At the start, mid-point (week 4) and end of 8 weeks of the assigned study intervention | Macro- and micronutrient analysis using the nutrition analysis platform Nutritics of 3-day food diaries administered at the start, mid-point and end of the assigned study intervention. |
| Change from baseline in insulin sensitivity at 2 months | At the start and end of 8 weeks of the assigned study intervention | HOMA-IR |
Countries
United Kingdom
Contacts
Primary ContactYana Petkova
Backup ContactDr Collins
Outcome results
None listed