Invasive Pulmonary Aspergillosis
Conditions
Keywords
Invasive Pulmonary Aspergillosis, Aspergillus fumigatus PCR, Bronchoalveolar lavage fluid
Brief summary
Aspergillus fumigatus PCR is currently used in conjunction with serum galactomannan to support the diagnosis of invasive aspergillosis or for monitoring at-risk patients not receiving antifungal prophylaxis. A positive result and a high titer are thought to be associated with the advanced stage of the disease and the fungal load. However, there is limited data on this subject, and no study has primarily focused on the variation of PCR levels during treatment and its potential correlation with treatment efficacy.
Interventions
None listed
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 years or older * Positive Aspergillus fumigatus PCR on serum or bronchoalveolar lavage fluid at diagnosis, performed at the Strasbourg University Hospital between January 1, 2017, and December 31, 2024.
Exclusion criteria
* No subsequent Aspergillus fumigatus PCR (\>24h) * No diagnosis of probable or proven invasive aspergillosis (EORTC/MSGERC 2020 criteria) * Effective antifungal treatment against Aspergillus initiated before the first PCR * Death \<72h after starting antifungal treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Death rate at day 30 in patients with a positive follow-up PCR (blood or bronchoalveolar lavage) | Day 30 post-antifungal treatment | Death rate at day 30 in patients with a positive follow-up PCR (blood or bronchoalveolar lavage) after the start of treatment |
Countries
France
Contacts
Primary Contactbaptiste Hoellinger, MD
Outcome results
None listed