CKD, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder, Pre-dialysis, Renal Insufficiency Chronic
Conditions
Keywords
Diet, Humans, Observational, Cohort, Phosphate/urine, Calcium/urine, Mineral bone disorder, Elderly, Calcium Balance, Phosphate Balance
Brief summary
The aim of the study is to assess the association between the calcium and phosphorus balance and the stage of kidney disease measured by creatinine clearence in patients with chronic kidney disease stage 4 and 5. The balance is measured a measurement between the recorded diatery intake and the urinary excretion. Additionally a comparison between image based diatery accessment and weighted records will be measured
Detailed description
All participants will be asked to take photos of all the food and fluids they consume during 24 hours. Additionally participants will be offered to weight their food and fluid for 3 days.
Interventions
None listed
Sponsors
Herlev Hospital
University of Copenhagen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* A glomerular filtration rate of \<30 ml ml/min/1.73m2 * 18 years and above
Exclusion criteria
None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Calcium and phosphate balance in relation to the stage of kidney disease | 3 days | Measured by the diatery intake of calcium and phosphate in relation to the urinary calcium and phosphate excretion |
| Comparison of diatery photograph method with weighted records. | 3 days | The intake of calcium and phosphate assesed by the 24 hour photos and the 72 hour weighing of food and fluid items will be compared. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Calcium intake total and the distribution of vegetarian and animal sources | 3 days | mg/day |
| Phosphate intake total and the distribution of vegetarian and animal sources | 3 days | mg/day |
| sodium intake total and the distribution of vegetarian and animal sources | 3 days | mg/day |
| Energy intake | 3 days | Kcal/day |
| Protein intake | 3 days | g/day |
| Fat intake | 3 days | g/day |
| Fluid intake | 3 days | ml/day |
| Plasma phosphate | 3 days | mmol/l |
| Plasma calcium | 3 days | mmol/l |
| Urinary Calcium | 3 days | mmol/day |
| Urinary urea | 3 days | mmol/day |
| Urinary sodium | 3 days | mmol/day |
| Plasma FGF23 | 3 days | mmol/l |
| P-calcium P- phosphate product | 3 days | Can be calculated by multiplying plasma calcium and plasma phosphate |
| plasma 25-OH-Vitamin D | 3 days | nmol/l |
| plasma PTH | 3 days | pmol/l |
| Plasma Albumin | 3 days | g/dl |
| eGFR | 3 days | ml/min/1.73m2 |
| Urinary creatinine | 3 days | mmol/day |
| Urinary phosphate | 3 days | mmol/day |
Countries
Denmark
Contacts
Primary ContactJens Rikardt Andersen, MD, MPA
Backup ContactJulian Askøe Bluming, RD
Outcome results
None listed