Obesity & Overweight
Conditions
Keywords
Exercise, obesity, extracellular vesicle, clinical assessment, physical fitness
Brief summary
This project aims to study the effect of exercise in the obesity/overweight on the changes of physical fitness and blood components. This will provide novel knowledge for medical staffs, researchers, or companies developing alternative strategies for treating obesity/overweight, including drug development and health promotion project to delay or prevent the onset of the disease.
Interventions
DEVICEHigh-intensity interval training exercise on treadmill
High-intensity interval training exercise using 65% to 80% of heart rate max
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
1. Male or female individuals aged between 25-45 years 2. Thai nationality 3. Ability to walk or perform daily activities independently, without the use of an assistive device 4. Body mass index (BMI) between 25-35 kg/m² 5. Low physical activity levels or sedentary lifestyle based on the World Health Organization 2020 * The levels of moderate-intensity physical activity \< 150-300 minutes per week or the levels of vigorous-intensity physical activity \< 75-150 minutes per week * Moderate-intensity physical activity: fast walking and bicycling. Vigorous-intensity physical activity: running, aerobic dance, and swimming All participants are required to meet all inclusion criteria to be eligible for the research project.
Exclusion criteria
1. Smoking, substance abuse, or alcohol addiction 2. History of respiratory diseases, such as asthma, emphysema, or chronic obstructive pulmonary disease 3. History of cardiovascular diseases, such as coronary heart disease, aortic disease, arrhythmia, or deep vein thrombosis 4. History of high blood pressure (hypertension) 5. History of vestibular system diseases, such as Meniere's disease or otitis media 6. History of neurological disease, such as severe Parkinson's disease or stroke 7. History of previous lower limb surgery, such as hip, knee, or ankle replacement 8. History of musculoskeletal diseases, such as severe osteoarthritis 9. History of severe brain disease, such as dementia 10. Severe visual or hearing impairment 11. Have a cognitive and comprehensive impairment and unable to complete the intervention 12. Have high physical activity or regularly exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body height | Pre-training (Day 1 before HIIT program) | Body height (cm) will be measured by stadiometer |
| Blood component assessment | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program within 1 hour) | Participant's blood components, e.g. extracellular vesicles, will be investigated by cell assays and proteomic analysis |
| Foot pressure distribution | 8 times: Day 1 (Before and after HIIT program), Day 4-7 (after HIIT program only), Day 18 (Before and after HIIT program) | Foot pressure distribution will be measured using a treadmill (Zebris FDM-T Treadmill System, zebris Medical GmbH, Germany) |
| Facial and abdominal fat thickness measurement | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) | Facial and abdominal fat thickness and characteristics will be pictured and analyzed using ultrasound imaging |
| VO2max | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) | VO2max parameter (ml/kg/min) will be examined using Cardio Pulmonary Exercise Test |
| Body composition | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) | Body composition (%) will be measured by bioelectrical impedance analysis. |
| Heart rate | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) | Heart rate (beat/min) will be measured by pulse oximeters |
| Grip strength | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) | Grip strength (kg) will be measured by hand grip dynamometer |
| Leg strength | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) | Leg strength (kg) will be measured by back-leg-chest dynamometer |
| Body weight | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) | Body weight (kg) will be measured by weighing scale |
Countries
Thailand
Contacts
Primary ContactOnaong Mee-inta, Ph.D.
Backup ContactPhunsuk Kantha, Ph.D.
Outcome results
None listed