Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.

Clinical and Tomographic Efficacy of the Modified Minimally Invasive Surgical Technique (M-MIST) Alone and Combined With Enamel Matrix Derivative (EMD) and Bone Mineral Derived Xenograft (BMDX), in the Treatment of Isolated, Inter-dental Intra-bony Defects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07310732

Enrollment

Registered

2025-12-30

Start date

2022-03-01

Completion date

2025-03-01

Last updated

2025-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Bone Loss, Periodontal Diseases

Brief summary

This study was performed to investigate the adjunctive clinical benefit of the application of enamel matric derivatives and xenograft with the modified minimally invasive surgical technique in the treatment of isolated intrabony defects in periodontally compromised subjects.

Interventions

PROCEDUREmodified minimally invasive surgical technique

modified minimally invasive surgical technique alone in interdental area

PROCEDUREmodified minimally invasive surgical technique plus emdogain

modified minimally invasive surgical technique with application of enamel matrix proteins in interdental area

PROCEDUREmodified minimally invasive surgical technique plus emdogain and xenograft

modified minimally invasive surgical technique with application of enamel matrix proteins and placement of bovine bone graft in interdental area

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* at least one site associated with an intrabony defect of ≥3 mm involving predominantly the interdental space of the tooth * patients with optimal compliance

Exclusion criteria

* Patients with uncontrolled or poorly controlled diabetes * history of long-term use of medications * allergic to medications * pregnant or lactating women * smokers/users of other tobacco products

Design outcomes

Primary

Measure	Time frame	Description
Probing Pocket Depth	24 weeks	The depth of probe penetration into the pocket (millimeters) is measured from the gingival margin using an UNC-15 probe.
Clinical Attachment Level	24 weeks	The distance from the base of the pocket to cemento-enamel junction (millimeters) is measured using an UNC-15 probe.

Secondary

Measure	Time frame	Description
Full mouth plaque score	24 weeks	Turesky Modification of Quigley-Hein Index used to assess plaque buildup across all tooth surfaces (buccal, lingual, mesial, distal) with scoring 0 (no plaque) to 5 (heavy plaque)
Full mouth bleeding score	24 weeks	Probe is inserted and withdrawn at the distal point of the tooth and monitored for bleeding within 10 seconds. Registered with (+) availability of provoked bleeding and with (-) its absence.
Mean defect depth	24 weeks	measured as the distance fromt the alveolar crest to the base of the defect (in CBCT)

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026