Esophageal Adenocarcinoma, Esophageal Anastomotic Leakeage, Esophageal Carcinoma, Esophagectomy, PaO2
Conditions
Keywords
Effect of Postoperative PaO₂ on Anastomotic Leakage Following Esophagectomy
Brief summary
This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. The investigators conducted a retrospective analysis of cases from their center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.
Detailed description
This retrospective study included all patients who underwent radical esophagectomy at our center over the past five years. After screening based on inclusion and exclusion criteria, PaO₂ levels within the first postoperative week were recorded (the lowest value was used if multiple measurements were taken on the same day), along with whether the condition improved after corrective interventions, patients were accordingly divided into Low Pa0₂ Group (at least one recorded instance of PaO₂ \<80 mmHg) and Normal Pa0₂ Group. Anastomotic leakage was diagnosed based on barium swallow, endoscopy, chest-abdominal CT, or typical clinical signs. By comparing the incidence of anastomotic leakage between the two groups, the relationship between postoperative PaO₂ and anastomotic leakage was analyzed, with further investigation into whether postoperative hypoxemia constitutes an independent and modifiable risk factor.
Interventions
None listed
Sponsors
Sun Yat-sen University
Sichuan Cancer Hospital and Research Institute
Affiliated Hospital of North Sichuan Medical College
Hebei Medical University Fourth Hospital
Affiliated Cancer Hospital of Shantou University Medical College
Shanghai Chest Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with esophageal carcinoma or benign esophageal tumors * Patients requiring surgical resection of the lesion with subsequent esophageal reconstruction * Patients must have had at least one postoperative arterial blood gas analysis * Patients must have routinely undergone at least one of the following for postoperative evaluation of the anastomosis: endoscopy, CT scan, or esophagram
Exclusion criteria
* Patients who did not require esophageal reconstruction * Patients undergoing esophageal replacement with colon * Patients with incomplete data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Esophageal Anastomotic Leakage Rate | From the date of surgery to 30 days postoperatively | Anastomotic leak was confirmed by either barium swallow study, CT scan, or endoscopy, or was clinically considered in cases with obvious salivary secretion from the cervical anastomosis. The esophageal anastomotic leakage rate was calculated as (the number of patients with a confirmed anastomotic leakage / the total number of patients who underwent esophagectomy) × 100%. |
Countries
China
Contacts
CONTACTHong Yang, M.D.
CONTACTYizhang Chen, M.D. candidate
PRINCIPAL_INVESTIGATORHong Yang, M.D.
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center
Outcome results
None listed