Brain Network Functional Connectivity
Conditions
Brief summary
Through longitudinal analysis of dynamic changes in DMN functional connectivity before and after sensory training intervention, combined with pain behavioral and functional improvement indicators, this study systematically reveals the central neural remodeling patterns in CNLBP and establishes an objective efficacy evaluation system based on multimodal imaging.
Detailed description
This phase of the research aims to elucidate the neuroplasticity mechanisms induced by CNLBP treatment, providing a theoretical basis for the future development of personalized rehabilitation protocols based on brain network subtypes, ultimately achieving the clinical goals of reducing pain recurrence rates and improving long-term prognosis in patients.
Interventions
OTHERMultimodal Imaging Evaluation
Functional connectivity analysis of brain networks based on functional magnetic resonance imaging (fMRI) technology
Sponsors
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18 and 60 years old; * Current or past low back pain lasting more than three months; ③ No abnormal sensation or reflex abnormalities in the lower limbs; ④ Able to commit to participating in training three times per week for three months.
Exclusion criteria
* Fractures, dislocations, structural abnormalities, prior surgery, metal implants, or lumbar disc herniation; * Comorbidities such as severe cardiovascular diseases, neurological disorders, osteoporosis, or metabolic diseases; ③ Low back pain caused by visceral diseases; * VAS score (range 1-10) exceeding 8 points; * Pregnant or lactating women; ⑥ Symptoms of nerve root irritation; ⑦ Recent participation in core stability training.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VAS | After 4 weeks of treatment | The Visual Analogue Scale (VAS) was used to assess the severity of low back pain, with 0 indicating no pain and 10 indicating unbearable severe pain. |
| JOA | After 4 weeks of treatment | The Japanese Orthopaedic Association (JOA) efficacy assessment criteria for low back disorders were applied to evaluate lumbar function. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MRI | After 4 weeks of treatment | Magnetic resonance imaging was used to assess the effects of treatment on brain networks. |
Contacts
Primary Contactyongxiang li
Backup Contactyali liu
Outcome results
None listed