Ventilated Patients
Conditions
Keywords
Mechanical ventilation, Tracheostomy, Nasal stimulation
Brief summary
The hypothesis of the present study is that restoring nasal stimulation alleviates dyspnea and improves respiratory drive. The aim of this study is to compare three non-pharmacological approaches designed to restore nasal stimulation (continuous nasal airflow, nasal sprays, and facial airflow) in tracheotomized patients dependent on mechanical ventilation.
Detailed description
Nasal stimulation is generated by breathing, which enables olfaction and helps to rhythm brain activity. The loss of nasal stimulation in tracheotomized patients who are dependent on mechanical ventilation may negatively affect respiratory drive and contribute to dyspnea. Restoring nasal airflow therefore emerges as an attractive non-pharmacological approach to treat dyspnea in patients undergoing mechanical ventilation weaning. The hypothesis of the present study is that restoring nasal stimulation alleviates dyspnea and improves respiratory drive. The aim of this study is to compare three non-pharmacological approaches designed to restore nasal stimulation (continuous nasal airflow, nasal sprays, and facial airflow) in tracheotomized patients dependent on mechanical ventilation.
Interventions
PROCEDUREBaseline
patient ventilated through the tracheostomy with initial ventilator settings
PROCEDUREInstallation of high flow humidified air cannula
Installation of high flow humidified air cannula with inspired oxygen fraction (FiO2) 21%
PROCEDURENasal air puffs
Nasal air puffs synchronized with the inspiratory time of the ventilator
PROCEDUREpropeller fan (FAN)
Stand-alone fan at the bedside directed toward the face of the patient
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years 2. Tracheostomy and mechanical ventilation 3. Dyspnea ≥3 4. Consent to participate 5. Affiliation to health insurance
Exclusion criteria
1. Agitation, delirium 2. Continuous use of sedatives 3. Patients under law protection 4. Inmates 5. Patients without health insurance 6. Breastfeeding and pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dyspnea | minute 20 | visual analogical scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| end expiratory occlusion pressure | minute 20 | visual analogical scale |
| respiratory electromyogram (EMG) | minute 20 | visual analogical scale |
| tolerance | minute 20 | visual analogical scale |
| airway occlusion pressure | minute 20 | visual analogical scale |
Contacts
CONTACTMartin DRES, MD PhD
PRINCIPAL_INVESTIGATORMartin Dres, MD PhD
Assistance Publique - Hôpitaux de Paris
Outcome results
None listed