Colon Cancer, Rectal Cancer
Conditions
Keywords
Colorectal Cancer, Lymph Node Metastasis, Spatial Distribution
Brief summary
The goal of this observational study is to learn about the spatial distribution and significance of metastatic lymph nodes in colorectal cancer patients. The main question it aims to answer is: * What is the spatial distribution pattern of metastatic lymph nodes in patients with colorectal cancer? * Can the spatial distribution pattern of metastatic lymph nodes in patients with colorectal cancer guide clinical practice? Participants should undergo regular follow-up examinations for at least 5 years after the surgery.
Interventions
None listed
Sponsors
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
China-Japan Friendship Hospital
Shanxi Province Cancer Hospital
Zhengzhou University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Aged between 18 and 80 years * Pathologically confirmed adenocarcinoma of the colon or rectum * Underwent radical resection for colorectal cancer with a D3 lymphadenectomy and lymph nodes were submitted for pathological examination according to standardized station-based and distance-based protocol * No distant metastasis or distant metastasis within 6 months after surgery * No history of other malignant tumors or severe systemic diseases * No immune diseases or inflammatory bowel diseases * Non-emergency surgery * With complete clinicopathological and follow-up data
Exclusion criteria
* Pathologically confirmed benign tumors or non-adenocarcinoma malignancies * Underwent local excision or palliative resection * Regional lymph nodes were not dissected or submitted for pathological examination according to the unified station-based or distance-based protocol * With distant metastasis or distant metastasis within 6 months after surgery * Dual or multiple primary colorectal cancers or concurrent other malignant tumors * Had a previous diagnosis of immune diseases or inflammatory bowel disease such as ulcerative colitis or Crohn's disease * Underwent emergency surgery * Had incomplete clinicopathological or follow-up data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The spatial distribution of metastatic lymph nodes | From enrollment to 14 days after surgery (at the completion of postoperative pathological examination) |
Secondary
| Measure | Time frame |
|---|---|
| Disease-free survival | From date of surgery until the date of first documented local recurrence, distant metastasis, or date of death from any cause, whichever came first, assessed up to 60 months |
| Overall survival | From date of surgery until the date of death from any cause, whichever came first, assessed up to 60 months |
Countries
China
Contacts
CONTACTHaizeng Zhang, Doctorate
STUDY_CHAIRHaizeng Zhang, Doctorate
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed