Vascular Infection Caused by C. Burnetii
Conditions
Keywords
vascular infection, vascular graft infection, vascular endograft infection, Coxiella burnetii
Brief summary
high morbidity and mortality. In France, Coxiella burnetii-related vascular infections appear to be increasing, though data remain limited. Two-year mortality reaches 15-18%, mainly due to serious complications such as arterio-digestive fistulas. Diagnosis is often delayed, prognostic factors are poorly defined, and the value of advanced imaging techniques remains insufficiently studied.
Detailed description
Q fever is a worldwide zoonosis that may cause chronic vascular infections with significant morbidity and mortality. In France, the incidence of Coxiella burnetii-related vascular infections appears to be increasing, although published data remain scarce. Reported two-year mortality reaches 15-18%, largely due to severe complications such as arterio-digestive fistulas. Classical risk factors include aortic aneurysm and vascular grafts, but many patients present without clear zoonotic exposure, leading to frequent underdiagnosis. Prognostic factors are poorly defined, apart from the lack of surgical management, which worsens outcomes. Diagnosis is often delayed, and the value of advanced imaging modalities such as 18F-FDG PET/CT or labeled leukocyte scintigraphy remains insufficiently studied.
Interventions
None listed
Sponsors
University Hospital, Bordeaux
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Adults (≥ 18yrs old) with native or prosthetic vascular infection due to C. burnetii (Jan 2000 - Dec 2023) * diagnosis based on CNR vascular Q fever criteria, * supplemented by MAGIC (Management of Aortic Graft Infection Collaboration) criteria for prosthetic/ - endovascular infections or aortitis/arteritis criteria, * no objection to reuse of patient data.
Exclusion criteria
* patient under legal protection, * insufficient French language comprehension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| two-year mortality rate | 2 years | from the time of initial management |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Early mortality rate | Day 30 | Early mortality rate (Day 30) |
| Infection-attributed mortality rate | 2 years | Infection-attributed mortality rate |
| Rate of postoperative complications | 2 years | Rate of postoperative complications |
| Rate of initial complications | 2 years | Rate of initial complications |
| Diagnostic performance of the different imaging modalities | 2 years | Diagnostic performance of the different imaging modalities |
| Two-year morbidity rate | 2 years | Two-year morbidity rate |
Countries
France
Contacts
Primary ContactMathilde Puges, MD
Backup ContactZoe Blanc, MD
Outcome results
None listed