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Effect of Perception-based Interventions on Public Acceptance of Using Large Language Models in Medicine

Perception-based Interventions Affect Public Acceptance of Using Large Language Models in Medicine: Randomized Controlled Trial

Status
Active, not recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07304908
Enrollment
3000
Registered
2025-12-26
Start date
2025-11-25
Completion date
2026-12-31
Last updated
2025-12-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acceptability of Health Care, Large Language Models, Perception, Self

Keywords

Large language model, Artificial intelligence, Perception-based interventions, Public acceptance

Brief summary

Large language models (LLMs) show promise in medicine, but concerns about their accuracy, coherence, transparency, and ethics remain. To date, public perceptions on using LLMs in medicine and whether they play a role in the acceptability of health care applications of LLMs are not yet fully understood. This study aims to investigate public perceptions on using LLMs in medicine and if interventions for perceptions affect the acceptability of health care applications of LLMs.

Detailed description

Owing to rapid advances in artificial intelligence, large language models (LLMs) are increasingly being used in a variety of clinical settings such as triage, disease diagnosis, treatment planning, and self-monitoring. Despite their potential, the use of LLMs remains restricted within healthcare settings due to lack of accuracy, coherence, and transparency and ethical concerns. Public perceptions such as perceived usefulness and risks play a crucial role in shaping their attitudes towards artificial intelligence that can either facilitate or hinder its adoption. Yet, to our knowledge, there is lack of awareness about perception-driven interventions in health care and no previous studies have examined whether public perceptions play a role in the acceptability of medical applications of LLMs. Hence, this study aims to investigate public perceptions on using LLMs in medicine and if interventions for perceptions affect the acceptability of health care applications of LLMs.

Interventions

OTHERPerception-based interventions

Participants allocated to the intervention group received perception-based interventions. Interventions for Groups 1-3 were perceived benefits of LLMs in medicine, perceived racial bias in LLMs in medicine, and perceived ethical conflicts in LLMs in medicine, respectively.

Sponsors

Peking University Third Hospital
CollaboratorOTHER
Peking University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* ≥18 years * Capable of completing an online survey * Agree to sign an informed consent form

Exclusion criteria

* Unable to answer questions or communicate * Not willing to participate in this study

Design outcomes

Primary

MeasureTime frameDescription
Number of participants who will change their attitudes towards medical applications of large language modelsThrough study completion, an average of 1 yearPublic acceptance of applying large language models to medicine will be categorized into yes, not sure, and no, which will be collected before perception-based interventions and after interventions.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026