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Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery

Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery on Airway Plateau Pressure: a Randomized, Prospective, Blinded Pilot Study

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07304479
Enrollment
50
Registered
2025-12-26
Start date
2025-05-01
Completion date
2026-02-28
Last updated
2025-12-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Mechanics, Intraoperative

Brief summary

Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.

Interventions

DRUGSevoflurane (Volatile Anesthetic)

Sevoflurane for robotic assisted laparoscopic surgery

DRUGDesflurane (volatile anesthetic)

Desflurane for robotic assisted laparoscopic surgery

Sponsors

National and Kapodistrian University of Athens
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 87 Years
Healthy volunteers
No

Inclusion criteria

* Age 18 to 87 years * Undergoing elective robotic-assisted abdominal surgery * ASA physical status I-III

Exclusion criteria

* ASA IV or V * Emergency surgery * Renal insufficiency * Clinically significant respiratory disease * Cardiomyopathy * Uncontrolled hypertension

Design outcomes

Primary

MeasureTime frameDescription
airway plateau pressurePerioperativelyAirway plateau pressure (cmH2O) as displayed on the anesthesia ventilator at the specified time points will be recorded for each participant.

Countries

Greece

Contacts

Primary ContactAliki Tympa, MD,PhD
alikitympa@med.uoa.gr00306955487575

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026