Analyze the Laterality of Endometriotic Lesions and Endometriosis-related Tumors, Endometriosis
Conditions
Brief summary
This study aims to understand whether endometriosis lesions - and tumors that can arise in association with endometriosis - occur more often on one side of the pelvis than the other. During surgery, doctors will record the exact location of each lesion to see if there is a consistent right- or left-sided pattern. Understanding these patterns may help improve knowledge about how endometriosis develops (pathogenesis), and thus improve its treatment.
Interventions
PROCEDUREsurgery
All patients enrolled in the study underwent surgery for endometriosis between 2013 and 2023.
Sponsors
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥18 years at the time of histological diagnosis of endometriosis * patients undergoing surgery with endometriotic lesions or patients with endometriotic lesions associated with endometrioid or clear cell ovarian cancer (Stage I-II) or borderline seromucinous ovarian cancer * first operation for endometriosis in the reference center (if recurrence consider only if both operations were performed at the reference center).
Exclusion criteria
* age \<18 years * patients affected by Stage I-II endometrioid or clear cell carcinoma or seromucinous borderline ovarian cancer not associated with endometriosis or in a more advanced stage of disease * women with an ultrasound diagnosis of endometriosis who have not undergone surgery * previous operations for endometriosis performed at another center
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Asymmetric distribution of endometriotic lesions on paired pelvic organs | At the time of index surgery | Proportion of patients presenting an asymmetric (right- or left-sided) distribution of endometriotic lesions on even and symmetrical pelvic organs (e.g., ovaries, uterosacral ligaments), based on the laterality observed and described during the index surgical procedure. Side-specific frequencies (right vs left) will be reported as number and percentage. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Asymmetric distribution of malignant ovarian lesions related to endometriosis | At the time of index surgery | Proportion of patients presenting an asymmetric (right- or left-sided) distribution of malignant lesions related to endometriosis-specifically endometrioid ovarian carcinoma, clear cell ovarian carcinoma, and seromucinous borderline tumors-based on the laterality observed and described during the index surgical procedure. Side-specific frequencies (right vs left) will be reported as number and percentage. |
Countries
Italy
Outcome results
None listed