Intra-procedural Spectral CT for Image-guided Embolization and Ablation in Interventional Oncology

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07303725

Enrollment

Registered

2025-12-26

Start date

2025-02-01

Completion date

2026-09-01

Last updated

2025-12-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cancer (Primary and Metastatic), Renal Cancer

Keywords

spectral CT

Brief summary

This is a pilot study to evaluate the feasibility, image quality, and procedural utility of a novel spectral CT technique using Canon Medical's 4D CT system during image-guided interventional oncology procedures

Detailed description

The aims of this study are: 1. Demonstrate the feasibility of acquisition and image quality of intra-arterial spectral CT images obtained during mapping arteriography prior to trans arterial radioembolization (TARE) for liver cancer treatment. 1. Assess the procedural utility of Spectral CT images as part of the TARE workflow, such as hepatopulmonary shunt fraction estimation, lesion identification, prediction of tumor: normal liver (T:N) dose ratio, and dose distribution 2. Investigate the feasibility, safety, and image quality of Spectral CT images obtained during tumor ablation. 2. Explore the feasibility of assessing physiologic tissue changes using Spectral CT (effective anatomic number maps) 1. During ablation with microwave, cryoablation, and irreversible electroporation in an ex vivo model 2. For image-guided tumor ablation, such as lesion identification, probe placement, and ablation monitoring.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age \> or = 18 years 2. Tumor in an area without prior surgical or ablative therapy 3. At least 1 tumor greater than 1.5 cm in greatest diameter

Exclusion criteria

1. Not eligible for indicated procedure. 2. BMI \> 35 3. Prior surgery.

Design outcomes

Primary

Measure	Time frame	Description
CT image	Baseline	Effective Dose and CTDI

Secondary

Measure	Time frame	Description
number	Baseline	Number of spectral CT acquisitions per patient
time	Baseline	Fluoroscopy Time

Countries

United States

Contacts

Primary ContactSirish Kishore, MD

sirish.kishore@va.gov650-493-5000

Backup ContactLuisa Manfredi, MPH

luisa.manfredi1@va.gov650-493-5000

Outcome results