Effect of Printing Layer Thickness on Growth of Candida Albicans in Completely Edentulous Patients Rehabilitated With 3D-Printed Maxillary Complete Denture Bases.

Effect of Printing Layer Thickness on Growth of Candida Albicans in Completely Edentulous Patients Rehabilitated With 3D-Printed Maxillary Complete Denture Bases: A Randomized Cross-over Study

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07303530

Enrollment

Registered

2025-12-26

Start date

2026-01-30

Completion date

2027-01-05

Last updated

2025-12-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Printed Dentures

Keywords

Candida

Brief summary

In completely edentulous patients rehabilitated with 3D-printed maxillary dentures bases, does the printing layer thickness affect candidal adherence and growth on the fitting surface of dentures.

Detailed description

The trial will follow a cross-over design, where each participant will wear denture bases printed with three different layer thicknesses (25 µm, 50 µm, and 100 µm) at a random order. Each participant will wear each of the three dentures for an 8-week period, with a washout period of two weeks between each thickness.

Interventions

DEVICEprinting layer thickness of denture

denture printed by multiple printing layer thicknesses to assess effect of layer thickness on fungal growth

Study design

Allocation

Intervention model

CROSSOVER

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Completely edentulous patients aged 30-80 years * Oral cavity is free from any mucosal lesions. * No systemic conditions that would contraindicate participation in the study.

Exclusion criteria

* History of allergic reactions to denture materials. * Active mucosal lesions related to denture use. * Pregnancy or lactation.

Design outcomes

Primary

Measure	Time frame	Description
Candidal growth	8-10 weeks	candidal growth over denture surface measured by colony-forming units (CFU)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026