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Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions

Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07302503
Acronym
BQ TC-foot
Enrollment
80
Registered
2025-12-24
Start date
2024-09-10
Completion date
2028-03-31
Last updated
2025-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Traumatic Encephalopathy

Keywords

Chronic Traumatic Encephalopathy, Post-traumatic lesions, Neurodegenerative brain abnormalities, Professional soccer players

Brief summary

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football. Soccer, due to repeated headers, could also be associated, albeit to a lesser degree, with the development of this type of pathology. Indeed, it has been shown that playing soccer can be accompanied by cognitive impairments, and neurodegenerative brain abnormalities have been described in neuropathology studies of former professional soccer players. Subradiological brain abnormalities have been found in multimodal MRI in various sports. Similarly, a decrease in cognitive performance has been described. The discovery of this type of anomaly in a population of professional footballers nearing the end of their careers could lead to: * The implementation of appropriate monitoring for professional footballers through early detection of lesions via MRI and cognitive disorders * The implementation of preventative measures for professional footballers, but also for amateur footballers from a very young age.

Interventions

None listed

Sponsors

University Hospital, Strasbourg, France
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
MALE
Age
32 Years to 60 Years

Inclusion criteria

* Male subject * Aged 32 to 60 years inclusive * Professional footballer nearing the end of their career or recently retired, or subject who has never regularly participated in sports that expose them to head trauma (particularly rugby, basketball, handball, American football, hockey, combat sports, etc.)

Exclusion criteria

\- Subject who expressed their opposition to participating in the study

Design outcomes

Primary

MeasureTime frame
Changes found in MRI diffusion tensor imaging of professional football playersday 1 post-consultation

Countries

France

Contacts

Primary ContactStéphane KREMER, MD, PhD
stephane.kremer@chru-strasbourg.fr33 3 88 12 78 48

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026