Gastroenteropancreatic Neuroendocrine Tumor
Conditions
Keywords
Gastroenteropancreatic Neuroendocrine Tumor, Neuroendocrine tumors, Gastroenteropancreatic, Gastrointestinal
Brief summary
Neuroendocrine tumors represent a heterogeneous group of tumors, of which gastrointestinal (gastroenteropancreatic) NETs are the most frequent. Therapeutic management involves several approaches: control of any secretory syndrome and tumor control. Surgery is the first-line treatment for localized stages. When there is distant metastasis, various systemic treatments can be combined or administered sequentially (somatostatin analogs, everolimus, sunitinib, radioablation, targeted internal radiotherapy, cytotoxic chemotherapy). Gastrointestinal NETs are most often well-differentiated and slow-growing tumors with a median overall survival of up to 9 years (all sites combined), making comprehensive management of these patients all the more important. In the context of cancer management, malnutrition has been shown to be associated with a poorer prognosis. Similarly, addressing malnutrition and improving nutritional parameters have been associated with improved prognosis. The impact of nutritional status in patients with slow-growing tumors such as gastrointestinal neuroendocrine tumors (NETs) is less well understood but could be a modifiable factor for improving quality of life and treatment efficacy. The research hypothesis is that nutritional status is associated with the prognosis of patients with gastrointestinal NETs.
Interventions
None listed
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 18 to 70 years * Patients being monitored for a digestive neuroendocrine tumor (gastric, pancreatic, intestinal), diagnosed between January 1, 2000, and November 30, 2024
Exclusion criteria
\- Tumor reclassified as non-neuroendocrine by histopathology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Establish a proportion of patients with malnutrition | Up to 12 months | The proportion of patients with malnutrition based on weight loss, compared to usual weight before the onset of illness, is distributed as follows: * weight loss ≥ 5% in 1 month or * weight loss ≥ 10% in 6 months |
Countries
France
Contacts
Primary ContactPhilippe BALTZINGER, MD
Outcome results
None listed