Deceased Donor Liver Transplantation Recipients, Living Donor Liver Transplantation Recipients, Living Liver Donor
Conditions
Keywords
liver transplantation, living donors, transplant recipients, follow-up studies
Brief summary
This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors. By collecting comprehensive clinical data and conducting systematic long-term follow-up, the researchers intend to establish a specialized, standardized, and individualized follow-up management system. The ultimate goal is to optimize intervention strategies and improve patient prognosis and quality of life for both recipients and donors.
Interventions
PROCEDUREliver transplantation
Patients undergo standard liver transplantation according to clinical protocols. Postoperative management and follow-up are conducted per routine standard of care. Clinical data, including survival, adverse events, and quality of life (assessed by questionnaires/scales), are collected observationally at regular follow-up intervals.
PROCEDURELiving Donor Hepatectomy
Living donors undergo standard hepatectomy procedures. Postoperative recovery and long-term health outcomes are monitored through routine follow-up visits and assessments.
Sponsors
Mukogawa Women's University
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients undergoing liver transplantation or living donor hepatectomy at the study center (living donor should be approved by the hospital ethics committee for living organ donation); 2. Age 18 years or older; 3. Willing to participate in the long-term follow-up management program; 4. Signed informed consent form;
Exclusion criteria
1. Patients undergoing combined organ transplantation 2. Patients with severe mental illness or cognitive impairment who are unable to cooperate with follow-up assessments. 3. Donors whose surgery is aborted intraoperatively for any reason. 4. Unable or unwilling to comply with the long-term follow-up schedule.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Long-term Incidence of Postoperative Adverse Events | From date of surgery up to 20 years | Evaluation of the cumulative incidence of postoperative complications |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival | Up to 20 years | — |
| Graft Survival Rate | Up to 20 years | — |
| Patient-Reported Outcome questionnaire | Baseline and annually up to 20 years | Assessment of multiple dimensions of patient health status, including physical functioning, mental health, social well-being, symptoms burden (e.g., pain, fatigue), and medication adherence. These domains will be evaluated using a battery of standard validated instruments |
Countries
China
Contacts
Primary ContactWen Fang
Outcome results
None listed