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Evaluation of Local Anesthetic Diffusion to the Sciatic Nerve During Adductor Canal Block

Evaluation of Local Anesthetic Diffusion to the Sciatic Nerve During Adductor Canal Block: an Observational Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07301476
Acronym
DiffuCAdd
Enrollment
70
Registered
2025-12-24
Start date
2025-12-10
Completion date
2027-12-31
Last updated
2025-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adductor Canal Syndrome, Sciatic Nerve

Keywords

Adductor Canal, Sciatic Nerve, Local anesthesia diffusion

Brief summary

Adductor canal block is an effective analgesic technique for major knee surgery. However, the saphenous nerve block is not sufficient to explain this block's efficiency. It has been shown that adductor canal block can spread to the tibial and fibular nerves through the adductor hiatus. However, this diffusion's frequency has never been measured. The main objective of this study is to assess clinically the frequency of the spread of the adductor canal block to the fibular and tibial nerves.

Detailed description

Adductor canal block is an effective analgesic technique for major knee surgery. The PROSPECT group recommends this block in first intention for locoregional anesthesia in total knee arthroplasty. It has been shown to not be inferior to femoral nerve block in this indication. The adductor canal block targets the saphenous nerve and, through its spread in the adductor canal, the posterior branch of obturator nerve and the vastus medialis nerve. However, these nerves can't fully explain this block's efficiency. It has been shown that local anesthetic can spread in the adductor canal to the tibial and fibular nerves through the adductor hiatus. However, this spread is inconstant, and no study has evaluated the frequency of this spread yet. The main objective of this study is to assess the diffusion's frequency of adductor canal block to fibular and tibial nerves through clinical sensorimotor testing.

Interventions

None listed

Sponsors

Assistance Publique - Hôpitaux de Paris
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* patients over 18 years old scheduled for elective knee surgery under general anesthesia * in our center * receiving an adductor canal block

Exclusion criteria

* patients cognitively impaired, * patients suffering from peripheral neuropathy at the lower limb, * patients receiving an IPACK block or surgical knee infiltration to complete the adductor canal block analgesia. * patients who refused to take part in this study * pregnant or breastfeeding patients * patients under guardianship * imprisoned patients, * patients without any medical insurance

Design outcomes

Primary

MeasureTime frameDescription
Frequency of local anesthetic's spread to tibial and fibular nerveat 4 hoursThe primary outcome is the frequency of local anesthetic's spread to tibial and fibular nerve during an adductor canal block, assessed by sensory and motor testing of these nerve territories. Sensorimotor testing will be performed at four hours with loco-regional anaesthesia.

Secondary

MeasureTime frameDescription
Frequency of reduction of sensitivity to cold or touch or reduction in MRC scoreat 1 hour and at 4 hoursFrequency of reduction of sensitivity to cold or touch or reduction in MRC score in fibular and tibial nerves territories assessed at one and four hours after the adductor canal block has been performed, as well as reduction of sensitivity to cold or touch in saphenous nerve territory assessed at one and four hours after nerve block.
Spread of the local anesthetic in the popliteal fossaat baselineQualitative assessment of local anaesthetic spread in the popliteal fossa on ultrasound recording (spread or no spread).
Evaluation of the positive and negative predictive valueat baseline and 1 hour, 4 hoursEvaluation of the positive and negative predictive value, sensitivity and specificity, and positive and negative likelihood ratio of ultrasound-visualised diffusion to the tibial and fibular nerves as a predictive test for clinical impairment of the sensitivity and motor function of these nerves at 1 hour or 4 hours
Clinical alteration assessementat Baseline and at 1 hour and 4 hoursClinical alteration of sensibility and motricity will be assessed before the adductor canal block is performed and then at H1 and H4. The ultrasound scan of the popliteal fossa will be performed at the same time as the local anaesthetic is administered.

Countries

France

Contacts

Primary ContactRomuald Henry, MD
romuald.henry@aphp.fr+ 33 06 72 83 17 51

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026