Interstitial Lung Diseases (ILD)
Conditions
Brief summary
The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives: Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different. Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs. Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.
Interventions
DIAGNOSTIC_TESTLung MRI Protocol with Functional and Contrast-Enhanced Sequences
Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations.
Sponsors
German Center for Lung Research
Thoraxklinik-Heidelberg gGmbH
University Hospital Schleswig-Holstein
University Hospital Heidelberg
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical indication for a routine HRCT because of either newly diagnosed idiopathic pulmonary fibrosis (IPF) or hypersensitivity pneumonitis (HP) or idiopathic non-specific interstitial pneumonia (iNSIP), suspected diagnosis, or follow-up * Capacity to consent * Ability to participate fully in the study (defined by the ability to lie still for the duration of imaging)
Exclusion criteria
* Pregnancy and breast feeding * Persons under the age of 18 and persons not able to give informed consent * Any medical conditions that could hinder the ability to adhere to the protocol * Any MRI contraindication, including previous allergic reactions to Gd-based MRI contrast material and renal dysfunction (eGFR \< 30 ml min/1,73 m2)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of ILD Subtypes Using Baseline MRI Metrics | Baseline (first MRI scan) | Assess whether baseline MRI metrics can accurately differentiate subtypes of interstitial lung disease, using clinician diagnosis (based on multidisciplinary discussion) as the reference standard. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of Longitudinal MRI Changes with Disease Progression | From enrollment (baseline MRI) through up to 1-year after enrollment; follow-up assessments will only be performed if clinically indicated. | Evaluate changes in MRI metrics over time and their correlation with ILD progression, using ATS/ERS/JRS/ALAT criteria. |
Countries
Germany
Outcome results
None listed