Obesity & Overweight, Vitamin D
Conditions
Keywords
overweight, obesity, vitamin D, 25-hydroxyvitamin D, high-intensity interval training
Brief summary
The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D \[25(OH)D\] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.
Detailed description
Thirty adults with overweight/obesity (both males and females) who will meet the inclusion criteria will be randomly assigned to either an Exercise group (n=15) or a Control group (n=15). The Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet. The Control group will receive a balanced diet but will not participate in exercise training. Both groups will provide a resting blood sample and undergo assessment of their body composition (via bioelectrical impedance analysis), daily dietary intake (via dietary recalls) and physical activity level (via accelerometry) at baseline (prior to intervention), 6 weeks and 12 weeks.
Interventions
OTHERExercise training
Receive a balanced diet and participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period
OTHERControl
Receive a balanced diet but abstain from any type of exercise training
Sponsors
University of Thessaly
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI = 25-35 kg/m2 * Absence of musculoskeletal injuries * Absence of chronic health-related complications * Non-smokers
Exclusion criteria
* Consumption of Vitamin D supplements * Consumption of anti-inflammatory drugs, statins and/or steroids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in 25-hydroxyvitamin D concentration | At baseline, 6 weeks and 12 weeks | 25-OH-VD will be quantitatively determined in serum |
| Change in plasma Vitamin D binding protein concentration | At baseline, 6 weeks and 12 weeks | Vitamin D binding protein concentration will be determined in plasma |
| Change in calcium concentration | At baseline, 6 weeks and 12 weeks | Calcium concentration will be determined in serum |
| Change in albumin concentration | At baseline, 6 weeks and 12 weeks | Albumin concentration will be determined in serum |
| Change in aspartate aminotransferase (SGOT) concentration | At baseline, 6 weeks and 12 weeks | SGOT concentration will be determined in serum on a Clinical Chemistry analyzer |
| Change in alanine aminotransferase (SGPT) concentration | At baseline, 6 weeks and 12 weeks | SGPT concentration will be determined in serum on a Clinical Chemistry analyzer |
| Change in gamma-glutamyl transferase (γ-GT) concentration | At baseline, 6 weeks and 12 weeks | γ-GT concentration will be determined in serum on a Clinical Chemistry analyzer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in reduced glutathione concentration | At baseline, 6 weeks and 12 weeks | Reduced glutathione concentration will be determined in blood erythrocytes |
| Change in oxidized glutathione concentration | At baseline, 6 weeks and 12 weeks | Oxidized glutathione concentration will be determined in blood erythrocytes |
| Change in dietary intake | At baseline, 6 weeks and 12 weeks | Dietary intake habits will be assessed through dietary recalls |
| Change in physical activity level | At baseline, 6 weeks and 12 weeks | Physical activity will be assessed via accelerometry |
| Change in body composition | At baseline, 6 weeks and 12 weeks | Body composistion will be assessed via bioelectrical impedance analysis (BIA) |
Countries
Greece
Contacts
CONTACTDimitrios Draganidis, PhD
CONTACTIoannis G Fatouros, PhD
PRINCIPAL_INVESTIGATORDimitrios Draganidis, PhD
University of Thessaly
Outcome results
None listed