Acute Respiratory Infection, Influenza-like Illness
Conditions
Brief summary
The purpose of this observational study is to compare the effectiveness of air surveillance and to better understand the relationship between household transmission and viruses detected in the air. Participants will provide nasal swabs and have an air sample surveillance device installed in their home.
Detailed description
The purpose of ORCHARDS-AIR is to utilize air surveillance in participant homes in conjunction with individually collected nasal specimens to assess their concordance and evaluate the significance of airborne detection with household transmission of common respiratory pathogens such as influenza and SARS-CoV-2. The researchers postulate that households with documented and probable respiratory pathogen transmission will have higher rates of in-home air surveillance detection. Students with more severe illnesses will be absent more often and spend more time at home, potentially leading to absenteeism being associated with greater air surveillance detections and intrahousehold transmission.
Interventions
DIAGNOSTIC_TESTNasal swab
Participants will use a swab to collect nasal specimens
DEVICEIndoor air quality monitor
InBio Apollo ambient air sampler to be run in the home for the duration of study participation. Material from the air, like aerosols, dust particles, and other environmental material, are collected on sampler filler material.
Sponsors
University of Wisconsin, Madison
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
4 Years to No maximum
Healthy volunteers
No
Inclusion criteria
- Students: * Student attends, or is eligible to attend, a school within the Oregon School District (OSD) * Study has an illness characterized by at least 2 of 6 acute respiratory infection (ARI)/ILI symptoms (nasal discharge, nasal congestion, sneezing, sore throat, cough, fever) and student scores at least 2 points on the Jackson scale
Exclusion criteria
- Students: * Household member listed on Wisconsin Department of Corrections Sex Offender Registry * Illness onset more than 7 days before anticipated time of specimen collection * Anatomical defect for which nasal specimen collection is contraindicated * Student participated too recently (\<7 days from day 14 during peak influenza / COVID-19 period and \<30 days during other times, as determined by a medically-attended surveillance program) Inclusion Criteria - Household member: * Live in the same household as eligible student participant * Any age and gender * Fluent in English * Able to provide appropriate consent or assent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of virus detection | Day 0, Day 7, Day 14 | Participants will provide nasal swabs, which will be tested for a panel of viruses. |
| Rate of air sampling detection among families with documented transmission | Day 7, Day 14 | Study team will collect and test air sampler filter for viruses. |
| Rate of air sampling detection among families without documented transmission | Day 7, Day 14 | Study team will collect and test air sampler filter for viruses. |
| Survey of symptoms - day 0 | Day 0 | Qualitative survey of participants' symptoms and related activities. |
| Survey of symptoms - day 7 | Day 7 | Qualitative survey of participants' symptoms and related activities. |
| Survey of symptoms - day 14 | Day 14 | Qualitative survey of participants' symptoms and related activities. |
| Air sampler use survey | Day 7, Day 14 | Qualitative survey about participants' use of the air sampler. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of absences | 14 days | Participants will self-report whether they were absent from school during the study period. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJonathan Temte, MD, PhD
University of Wisconsin, Madison
Outcome results
None listed