Oct Angiography Changes After Local Anesthesia in Cataract Surgery

OCT Angiography Changes of Retinal Microvasculature After Local Anesthesia in Cases Undergoing Cataract Surgery

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07298746

Enrollment

100

Registered

2025-12-23

Start date

2025-12-31

Completion date

2027-03-31

Last updated

2025-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

OCTA Changes With Local Anesthesia

Keywords

OCTA , local anesthesia

Brief summary

Assessement of retinal microvasculature detected by OCT-angio after peribulbar &retrobulbar anesthesia in cases undergoing cataract surgery .

Detailed description

prospective , interventional,comparative , clinical study utilizing a pre-post, within-subject design ,which will be conducted in the Department of Ophthalmology ,Sohag University Hospital ,Egypt. Optical coherence tomography angiography (OCTA) will be performed before and after the administration of retrobulbar and peribulbar local anesthesia in the same cohort of patients, in order to evaluate the immediate effects of the anesthetic intervention on retinal microvascular parameters.the study will be conducted on patients aged 40-80 years with elective cataract surgery requiring regional block.the study will be divided into two main groups : 1. Group with peribulbar anesthesia injection. 2. Group with retrobulbar anesthesia injection.

Interventions

DRUGLocal Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML)

peribular injection of both lidocaine 2 % and hyaluronidase 150IU\\ML

DRUGLocal Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)

peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML

DRUGLocal Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML)

retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\\ML

DRUGlocal Anesthesia (retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)

retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. patients aged 40-80 years. 2. patients with elective cataract surgery requiring regional block.

Exclusion criteria

* 1.Allergy to study drugs. 2. Media opacities affecting OCT imaging (corneal pathologies, dense cataracts, vitreous. opacities, etc). 3. Patients with any other retinal vascular diseases (retinal vein occlusion, central serous chorioretinopathy, age-related macular degeneration, etc). 4\. Patients who have had previous intravitreal injections or Laser treatment. 5. Patients who underwent previous vitreoretinal surgeries. 6. Patients with uncontrolled glaucoma or ocular inflammations (eg: vitritis). 7.Patients with diabetes mellitus or hypertension.

Design outcomes

Primary

Measure	Time frame	Description
Macular superficial capillary plexus (SCP) and deep capillary plexus (DCP	ntervention & data collection :4-6 monthes	to detect degree of changes in vessel density at superficial and deep macular plexuses before and after injection of each group of anesthesia

Contacts

Primary ContactAmira aldesoky abdelazeem ahmed, resident

amera.desouky@med.sohag.edu.eg01055330581

Backup ContactMohamed Anber Abdellatif, professor

01009801966

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026