Metabolic Syndrome, Prolonged Inactivity
Conditions
Keywords
Exercise, metabolic syndrome, insulin resistance, virtual reality
Brief summary
Prolonged sedentary conditions contribute to declining health across human populations and cause significant secondary health consequences for many patients whose illnesses or injuries prevent them from exercising. The investigators have demonstrated that in a small animal fruit fly model, genetic stimulation of neurons that promote adrenergic signaling is sufficient to mimic the benefits of exercise training even in sedentary animals. The investigator's pilot work in humans has confirmed that humans respond to Virtual Reality (VR) stimuli that mimic exercise by increasing heart rate and altering heart rate variability in a way consistent with increased adrenergic activity. In this study, the investigators will directly test for the first time whether repeated, controlled exposure to VR stimuli that induce adrenergic activity in sedentary humans can produce adaptive changes to protein expression and endurance performance like those produced by actual exercise in pre-diabetic participants with/without hypertension.
Interventions
BEHAVIORAL20 minutes cycling exercise
20 minutes cycling exercise
BEHAVIORALVirtual Reality
20 minutes virtual cycling
Sponsors
National Institute on Aging (NIA)
Wayne State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
1. Equal numbers male and female (32 each) 2. Blood glucose HbA1C: 5.7-6.4% or 100-125 mg/dL 3. BP: systolic\<120 and diastolic\<80 mmHg, systolic 120-129 mmHg and diastolic \<80 mmHg, or systolic \>130 mmHg and diastolic \>80 mmHg
Exclusion criteria
1. BMI\>35kg/m2 2. Currently involved in an exercise program or similar activity 3. Taking medications that could affect results, including beta-blockers or SSRIs 4. Demonstrate any form of discomfort with the VR experience through self-reported feelings of anxiety or nausea 5. Alcohol consumption above a minimal level(\<2 oz/night) 6. BP: Systolic \>160 mmHg and Diastolic \>110 mmHg
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Glucose, HbA1C | 10 weeks | Pre-diabetic patients (Blood glucose 100-125 mg/dL, AbA1C 5.7-6.4%) may see improvement in values post-intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 10 minute walk time | 10 weeks | distance walked in 10 minutes is recorded pre- and post- intervention and may improve |
Countries
United States
Contacts
Primary ContactAlyson Sujkowski, PhD
Backup ContactRobert J Wessells, PhD
Outcome results
None listed