Transforming Research and Clinical Knowledge in Geriatric Traumatic Brain Injury (TRACK-GERI)

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07296783

Acronym

TRACK-GERI

Enrollment

1500

Registered

2025-12-22

Start date

2019-09-02

Completion date

2027-01-31

Last updated

2025-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic Brain Injury

Brief summary

The purpose of this study is to improve the diagnosis and prediction of recovery after traumatic brain injury (TBI) in adults age 65 years and older. The study will follow older adults who present to the emergency department after TBI, as well as matched control participants, and will measure clinical features, brain imaging, and blood-based biomarkers over 12 months to understand how recovery changes over time. Researchers will examine how pre-injury health, brain structure, and biological markers are related to disability and cognitive outcomes after TBI. Information from this study will be used to develop age-appropriate tools to better diagnose TBI and estimate long-term outcomes in older adults.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

TRACK-GERI/VA TBI PATIENT INCLUSION/

Exclusion criteria

Inclusion Criteria: 1. Age 65 years and older, no upper age limit 2. Reliable report or physical evidence of head trauma 3. Injury occurred \<72 hours ago (within 14 days of injury for TRACK-VA TBI patients) 4. Acute brain CT for clinical use 5. Fluency in English/Chinese (UCSF only) 6. Ability to obtain informed consent from subject or legally authorized representative 7. Ability to be co-enrolled with a study partner who meets Study Partner enrollment criteria

Design outcomes

Primary

Measure	Time frame	Description
Functional Outcome at 6 Months Post-Injury as Assessed by the Glasgow Outcome Scale-Extended (GOSE)	6 months post-injury	Functional outcome after traumatic brain injury will be measured using the Glasgow Outcome Scale-Extended (GOSE). The score ranges from 1-8, with higher scores indicating better recovery. The primary outcome is GOSE assessed at 6 months post-injury.

Countries

United States

Outcome results