Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy

Laparoscopic Cholecystectomy Patients: Effect of Sevoflurane vs. Desflurane on Mechanical Power - A Prospective, Randomized, Controlled Trial

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07295158

Acronym

VAPOR

Enrollment

138

Registered

2025-12-19

Start date

2026-03-09

Completion date

2026-09-10

Last updated

2026-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Respiratory Mechanics

Brief summary

This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).

Interventions

DRUGSevoflurane

General anesthesia will be maintained with sevoflurane at 2% concentration in patients assigned to the Sevoflurane Group (Group S). Standardized ventilator settings will be applied for all participants, and mechanical power will be measured at three intraoperative time points while sevoflurane is used as the sole maintenance inhalational agent.

DRUGDesflurane

Maintenance of general anesthesia with desflurane 6% during laparoscopic cholecystectomy. Mechanical power is measured at three intraoperative time points using standardized ventilator settings.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Masking description

Participants and postoperative outcome assessors are masked to group allocation. The anesthesia team administering sevoflurane or desflurane is not blinded, but all intraoperative data collectors and postoperative evaluators remain blinded to the inhalational agent used. Randomization is performed using sealed opaque envelopes to maintain allocation concealment.

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Adults aged 18-65 years ASA Physical Status I-II Scheduled for elective laparoscopic cholecystectomy Able to provide written informed consent

Exclusion criteria

Known hypersensitivity or contraindication to study medications (sevoflurane or desflurane) Severe chronic obstructive pulmonary disease (COPD) Uncontrolled bronchial asthma Decompensated heart failure (NYHA Class III-IV) History of prior lung surgery Morbid obesity (BMI \> 35 kg/m²) Pregnancy Refusal to participate or inability to provide informed consent \-

Design outcomes

Primary

Measure	Time frame
Mechanical Power (MP) during General Anesthesia	Measured at three intraoperative time points: Post-intubation baseline (MP1) 15 minutes after pneumoperitoneum (MP2) End of surgery before emergence (MP3)

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 16, 2026