Cardiovascular Diseases (CVD)
Conditions
Brief summary
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and their prevalence is steadily increasing in Morocco. Between 2010 and 2012, the All with heart Association conducted a large-scale cardiovascular screening campaign in the Greater Casablanca region, involving more than 10,000 adults aged over 40 years. This 10-year follow-up study aims to evaluate long-term cardiovascular outcomes and to develop a Morocco-specific cardiovascular risk score. Follow-up data will be collected through phone calls, WhatsApp, or SMS with participants or their families to document cardiovascular deaths, myocardial infarctions, and strokes. Statistical analyses, including survival analysis and multivariate logistic regression, will be used to identify significant risk factors and to construct a predictive risk model tailored to the Moroccan population. The study received a favorable opinion from the Rabat Ethics Committee. Written informed consent will be obtained from all participants or their families prior to data collection. The findings are expected to enhance understanding of cardiovascular risk evolution in Morocco and to provide a validated, population-specific risk score to support prevention and patient management strategies.
Interventions
None listed
Sponsors
F&C Clinical Trials
Moroccan Society of Cardiology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged 40 years or older at the time of the initial screening (2010-2012). * Individuals who participated in the cardiovascular risk screening campaign conducted by the All with heart Association between 2010 and 2012 in the Greater Casablanca region. * Moroccan nationality. * Participants or family members who provide written informed consent for participation in the 10-year follow-up study.
Exclusion criteria
* Individuals who refuse to participate in the follow-up study. * Participants who have moved and cannot be reached by phone, WhatsApp, or SMS. * Participants who died from non-cardiovascular causes. * Non-Moroccan participants.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Major Cardiovascular Events (MACE) | 10 years after initial screening (2010-2012) | Occurrence of major cardiovascular events (myocardial infarction, stroke, or cardiovascular death) among participants screened for cardiovascular risk between 2010 and 2012 by the All with heart Association. Events will be identified during the 10-year follow-up period through participant or family contact (phone, WhatsApp, or SMS) and verified through available medical records when possible. |
| Development and Validation of a Morocco-Specific Cardiovascular Risk Score | Baseline (2010-2012) and 10-year follow-up (2022) | Development and internal validation of the Morocco-Specific Cardiovascular Risk Score, a composite risk prediction score estimating the 10-year probability of major cardiovascular events including myocardial infarction, stroke, or cardiovascular death. The score will be derived from baseline cardiovascular risk factors collected during the initial screening and weighted using multivariable regression models based on outcomes observed during the 10-year follow-up. The score will be expressed on a scale ranging from 0 to 100, where higher scores indicate a higher cardiovascular risk and therefore a worse outcome. Model performance will be assessed using discrimination and calibration measures, including the area under the receiver operating characteristic curve and calibration analyses. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Minor Cardiovascular Events | 10 years after initial screening (2010-2012) | Occurrence of minor cardiovascular events, including stable or unstable angina, among participants screened between 2010 and 2012. Events will be collected through participant or family interviews and verified with medical records when available. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Number of Hospitalizations Related to Cardiovascular Diseases | 10 years after initial screening (2010-2012) | Total number of hospitalizations due to cardiovascular causes (acute coronary syndrome, heart failure, arrhythmia, or cardiac surgery) during the 10-year follow-up period. |
| Change in Cardiovascular Risk Factors Over Time | 10 years after initial screening (2010-2012) | Change in major cardiovascular risk factors (body mass index, blood pressure, total cholesterol, triglycerides, HDL, blood glucose, smoking status, and physical activity) between the initial screening and the 10-year follow-up. |
| Quality of Life Assessment | 10 years after initial screening (2010-2012) | Evaluation of participants' quality of life using a standardized questionnaire (EQ-5D). The assessment will explore mobility, self-care, usual activities, pain/discomfort, and anxiety/depression dimensions. |
Countries
Morocco
Contacts
Primary ContactNajat MOUINE, Professor of Cardiology
Backup ContactMohamed ALAMI
Outcome results
None listed