Broncheictasis
Conditions
Keywords
broncheictasis, N-acetylecysteine
Brief summary
It has been deduced that reducing the production of mucus or improving the clearance of sputum in the airway is the key to enhance the therapeutic efficacy for bronchiectasis . Mucoactive drugs are commonly used to clear the airway in mucus hypersecretion diseases. Currently, investigators have found that N-acetylcysteine (NAC), an effective mucolytic agent, not only reduces the viscosity and elasticity of sputum, but it also has anti-inflammatory and antioxidant activity. Additionally, the Spanish guidelines on the treatment of bronchiectasis indicate that the use of N-acetylcysteine should be considered for patients with bronchiectasis and COPD. Therefore, as a classic mucolytic agent with antioxidant and anti-inflammatory properties, N-acetylcysteine can be effective in the treatment of bronchiectasis
Interventions
DRUGN Acetyle cysteine given by IV injection
Arm: IV N Acetyle cysteine
DRUGNebulized N Acetyle cysteine
Arm: Nebulized N Acetyle cysteine
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects aged above 18 years old; with a diagnosis of bronchiectasis who are admitted to chest department due to acute exacerbation
Exclusion criteria
* current smokers, a known allergy to N-acetylcysteine; pregnancy or lactation (for women); primary diagnosis of COPD or asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sputum viscosity score | At the end of 1 week of treatment | Sputum viscosity score \\(0\\): Normal (liquid)\\(1\\): Mildly increased viscosity (fluid)\\(2\\): Moderately increased viscosity (viscous)\\(3\\): Severely increased viscosity (sticky) |
| Amount of sputum | At the end of 1 week treatment | — |
| Expectoration difficulty score | At the end of 1 week of treatment | Expectoration difficulty score \\(0\\): No difficulty\\(1\\): Mild difficulty\\(2\\): Moderate difficulty\\(3\\): Marked difficulty |
Secondary
| Measure | Time frame |
|---|---|
| Need for mechanical ventilation | At the end of 1 week of treatment |
Outcome results
None listed