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Serum Hyperbilirubinemia as an Early Predictive Factor for Complicated Appendicitis: Single Center Experience

Serum Hyperbilirubinemia as an Early Predictive Factor for Complicated Appendicitis: Single Center Experience

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07291882
Enrollment
400
Registered
2025-12-18
Start date
2024-09-01
Completion date
2025-08-20
Last updated
2025-12-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appendicitis, Surgery

Brief summary

Serum total bilirubin provides a practical guide to early assessment of suspected appendicitis, supporting faster and more proportionate decisions-earlier escalation when overall risk is high and safe observation when it is low. Because testing is rapid, inexpensive, and universally available, integration into local diagnostic pathways is feasible.

Interventions

PROCEDUREAppendectomy

Total bilirubin levels was measured preoperatively as part of the routine laboratory workup. Appendectomy done for all patients followed by histopathological evaluation of the excised appendix.

Sponsors

Minia University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* All patients presented with right iliac fossa pain diagnosed clinically as acute appendicitis and had undergone appendectomy

Exclusion criteria

* patients with past history of jaundice * patients with history of hyperbilirubinemia hemolytic disease * positive hepatitis viruses * cholelithiasis * acquired or congenital biliary disease * cancer of the hepatobiliary system

Design outcomes

Primary

MeasureTime frame
measurement of serum total bilirubin in each case of appendicitis to clarify the relationship between serum hyperbilirubinemia and complicated appendicitisbetween September 2024 and August 2025

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026