Polycystic Ovary Syndrome, Psoriasis
Conditions
Brief summary
Women with psoriasis usually develop many complications including polysyctic ovarian syndrome (PCOS). Nowdays, diet restriction combimed with phsyical exercises may improve both problems
Detailed description
Forty Women with psoriasis with PCOS will be enrolled to be catogrized to Group I or group II. Group I will enroll twenty females with PCOS and Psoriasis who will apply forty minutes walking on treadmill three times per week. Also Group I will follow low calorie diet and daily metformin for 12 weeks. Group II will will enroll twenty females with PCOS and Psoriasis who will follow low calorie diet and daily metformin for 12 weeks
Interventions
BEHAVIORALexercise and diet restriction
Group I will enroll twenty females with PCOS and Psoriasis who will apply forty minutes walking on treadmill three times per week for 12 weeks. Also Group I will follow low calorie diet and daily metformin for 12 weeks.
BEHAVIORALdiet restriction
Group II will will enroll twenty females with PCOS and Psoriasis who will follow low calorie diet and daily metformin for 12 weeks
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* obese (class I) women * chronic plaque psoriasis * polyscytic ovarian syndrome
Exclusion criteria
* cardiac dysfucntions * liver diseases * repsiratory disease * vascular diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Psoariasis area and severity index | it will be measured after 12 weeks | is an index used to express the severity of psoriasis. It combines the severity (erythema, induration and desquamation) and percentage of affected area |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dehydroepiandrosterone | It will be measured after 12 weeks | it will be assessed in plasma |
| body mass index | It will be measured after 12 weeks | it will be assessed after emptying bladder and bowel |
| waist circumference | It will be measured after 12 weeks | it will be measured at level of ambilicus |
| waist hip ratio | It will be measured after 12 weeks | it will be assessed after dividing waist circumference on hip circumference |
| testesterone | it will be measured after 12 weeks | it will be assessed in serum |
| Dermatology life Quality Index | It will be measured after 12 weeks | it assess impact of skin disease on quality of life |
| insuiln | It will be measured after 12 weeks | it will be assessed in plasma |
| ratio of luteinizing hormone and follicle-stimulating hormone | It will be measured after 12 weeks | it is anindicator on function of sex hormones |
| HOMA-IR | It will be measured after 12 weeks | Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) is classically considered to be a good insulin resistance (IR) index |
| triglycerides | It will be measured after 12 weeks | it will be assessed in plasma |
| total cholesterol | It will be measured after 12 weeks | it will be assessed in plasma |
| high density lipoprotein | It will be measured after 12 weeks | it will be assessed in plasma |
| low density lipoprotein | It will be measured after 12 weeks | it will be assessed in plasma |
| systolic blood pressure | It will be measured after 12 weeks | it will be assessed via manual sphygmmanometer |
| diatolic blood pressure | It will be measured after 12 weeks | it will be assessed via manual sphygmmanometer |
| fasting blood glucose | It will be measured after 12 weeks | it will be assessed in plasma |
Countries
Egypt
Contacts
Primary ContactAli MA Ismail, lecturer
Backup ContactAli mohamed, lecturer
Outcome results
None listed