Thalassemia Majors (Beta-Thalassemia Major)
Conditions
Keywords
INSL3 or inhibin B hormone in transfusion depandant beta thalassemia
Brief summary
Patient with transfusion depandant beta thalassemia with accumulation of iron in their body affect pituitary gland and gonades lead to impaired their functions .
Detailed description
detection of any abnormalities in pituitary gland hormones ( FSH , LH , serum prolactin ) gonadal hormones ( serum testesterone , antimullerian hormone , INSL3 , inhibin B hormone )
Interventions
DIAGNOSTIC_TESTserum inhibin B serum INSL3 serum AMH
transfusion depandant beta thalassemia with measure gonadal function serum INSL3 serum inhibin B serum AMH
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
10 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* transfusion depandant beta thalassemia * age 10 to 18 year old age
Exclusion criteria
* age below 10 year old age or above 18 year old age * associated with another disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gonadal function in transfusion depandant beta thalassemia | through study completion, an average of 1 year | gonadal function assessment by Inhibin B hormone, INSL3 , serum testesterone that analysed in patient with age 10 - 18 year old for early detection of any abnormality |
Contacts
Primary ContactHager Saadeldin saadeldin, pediatric resident
Backup ContactAhmed Ahmed Moniur Hegab, Doctor
Outcome results
None listed