Surgical Evacuation Versus Methotrexate Injection in Treatment of Caesarean Scar Pregnancy [Clinical Trial ]

Ultrasound Guided Surgical Evacuation Versus Combined Local and Systemic Methotrexate Injection for Management of Caesarean Scar Pregnancy [Clinical Trial ]

Status

Not yet recruiting

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07288307

Enrollment

Registered

2025-12-17

Start date

2026-01-20

Completion date

2027-02-01

Last updated

2025-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caesarean Scar Pregnancy

Brief summary

The aim of the study is to compare the effectiveness and the complications of Ultrasound guided surgical evacuation versus using combined local and systemic methotrexate injection for management of caesarean scar pregnancy.

Interventions

PROCEDURESurgical evacuation and methotrexate injection

Surgical evacuation of the scar pregnancy using ultrasound and local and systemic methotrexate injection

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

Gestation age Less than 12 weeks. Hemodynamically stable patient with un ruptured CSP. Non disturbed scar pregnancy . Acceptance of possible prolonged follow up, repeated HCG tests, the need for additional treatment doses and possible bleeding and subsequent hysterectomy. \-

Exclusion criteria

* Patient refuse TOP. Gestation age More than 12 weeks . Hemodynamically unstable patient with ruptured CSP. Contraindication for methotrexate as hepatic disorders, renal disorders ,hypersensitivity to the drug and autoimmune diseases.

Design outcomes

Primary

Measure	Time frame	Description
Success rate of treatment either by surgical evacuation or by methotrexate injection	Up to 8 weeks post -intervention	The proportion of participants achieving complete resolution of caesarean scar pregnancy without the need of additional intervention

Secondary

Measure	Time frame
The need for additional intervention	Up to 8 weeks post -intervention
Time for serum-hCG normalisation (days).	Up to 8 weeks post -intervention
Bleeding during the procedure	Up to 8 weeks post -intervention
Uterine perforation.	Up to 8 weeks post -intervention
Occurrence of drug complications	Up to 8 weeks post -intervention
Hospital stay (days).	Up to 8 weeks post -intervention

Contacts

Primary ContactBadr Atef AbdAllah, MD

dr.badratef@gmail.com+201092975253

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026