Diabete Mellitus
Conditions
Keywords
Diabetic, A-PRF, Extraction, Socket
Brief summary
To evaluate soft tissue closure in diabetic extraction sockets using digital scans. To compare healing between sockets treated with Advanced Platelet Rich Fibrin (A-PRF) vs. untreated control sites. To assess post-operative discomfort and patient satisfaction.
Interventions
PROCEDUREPlatelet rich fibrin
Description: A-PRF is a biologically active scaffold that fits into the proven principles of the physiology of the wound-healing process. Its action lies in the controlled and prolonged release of fundamental factors like the PDGF (platelet-derived growth factor), TGF-β (transforming growth factor beta), and VEGF (vascular endothelial growth factor) which collectively enhance cellular migration, angiogenic events, and extracellular matrix remodeling factors of repair in the recovery of the tissues.
Sponsors
King Abdulaziz University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Eighteen years or older * Need bilateral tooth extraction * Sockets should be the same size * Diabetic/ uncontrolled * No other disease * Non- smoker * Non-pregnant or lactating female
Exclusion criteria
* Patients below 18 years * Patients with diseases different from diabetes * Bleeding disorders * Pregnancy * Lactation, * Tobacco use (conventional or electronic)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Socket size | 3 weeks | Soft tissue healing of extraction sockets |
Countries
Saudi Arabia
Outcome results
None listed