Glioma, Parietal Lobe Glioma, Unilateral Spatial Neglect (USN), Visuspatial Deficit
Conditions
Keywords
Visuospatial deficit, Glioma, Parietal Lobe, Neuropsychological assessment, Hemineglect
Brief summary
The goal of modern neurooncological surgery is to obtain maximum tumor resection while preserving neurological function. Parietal lobe gliomas often cause attention deficits (hemineglect) that are difficult to differentiate from other deficits. This study aims to evaluate the extent and variation over time of visuo-spatial deficits in patients undergoing surgical removal of parietal lobe gliomas. This will help characterize the cognitive profile of these patients to identify personalized treatment and rehabilitation paths.
Detailed description
This is a single-centre, prospective, cross-sectional, observational study involving 40 patients with high- and low-grade parietal lobe glioma. The study investigates the prevalence of subjects who show a performance in cognitive visuo-spatial tests below the cut-off of the normative sample. It evaluates associations with patient-reported outcome measures (ADL, IADL), clinical-demographic aspects, radiological data (MRI), and histological/molecular data. Assessments occur at screening (pre-surgery), and at follow-up visits (3-4 months and 6 months post-surgery). Neuropsychological tests include Line Bisection, Bell and Letter Cancellation, Reading test, Apple Cancellation, and Fluff test.
Interventions
None listed
Sponsors
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients \>18 years old * Patients must understand the Italian Language * Patients with suspected parietal lobe glioma
Exclusion criteria
* Tumor site other than parietal lobe. * Patients who cannot undergo surgical resection (stereotactic/open biopsy). * Patients who received a previous chemotherapy and/or radiotherapy treatment. * Patients with a history of intracranial mass lesion or traumatic brain injury. * Patients with a history of other CNS diseases (e.g., stroke, metastasis). * Patients with diagnosis of neurodegenerative disease (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy Body Dementia, Amyotrophic Lateral Sclerosis).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Visuospatial Deficit Prevalence | Baseline (pre-surgery), 3-4 months post-surgery, 6 months post-surgery. | Prevalence of patients with a score below the cut-off in specific neuropsychological tests for visuo-spatial aspects (Line Bisection, Bell/Letter Cancellation, Apple Cancellation, Fluff Test) and the extent of change compared to baseline. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association with Performance Status | Time Frame: Up to 6 months post-surgery. | Correlation between visuo-spatial scores and Karnofsky Performance Status (KPS). |
| Association with Radiological Data | Up to 6 months post-surgery | Correlation between visuo-spatial deficit scores and MRI data (FLAIR volume, T1 contrast, necrosis, localization). |
| Association with Clinical-Demographic Data | Up to 6 months post-surgery. | Correlation between visuo-spatial scores and hemispheric dominance, age, sex, and education. |
| Association with Histological/Molecular Data | Up to 6 months post-surgery. | Correlation between visuo-spatial scores and tumor grade, histological and molecular features. |
Countries
Italy
Contacts
Primary ContactFrancesco Di Meco, MD
Outcome results
None listed